Synthesis of Schiff bases of coumarin and their antifungal activity
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Date
2017
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Punjab Agricultural University, Ludhiana
Abstract
Schiff bases of coumarin were synthesized from 7-hydroxy-4-methylcoumarin and aromatic
amines. Micro analytical data, UV-Visible data, FT-IR, 1HNMR and 13CNMR were used to
elucidate the structure of synthesized compounds. All the synthesized compounds were
screened in vitro for their antifungal activity against Helminthosporium sp. and Fusarium sp.
at 10-1000 µg/ml by spore germination inhibition technique. The synthesized compounds had
shown excellent antifungal potential but Schiff base (7d) had shown broad spectrum activity
against both test fungi.
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