EFFECT OF MYCOBACTERIAL LIPOARABINOMANNAN ON INTERLEUKIN-2 PRODUCTION BY BOVINE LYMPHOCYTES
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Date
2006-07
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Abstract
Lipoarabinomannan (LAM) is a major
antigen of mycobacterial envelope, which
exhibits a large spectrum of immunological
activities. The intact and fully antigenic LAM
of M-tubercu/osis causes inhibition of T cell
proliferation. Some of the cytokines
produced in response to high concentration
of LAM at the site of infection may mediate
the depressed lymphocyte proliferation to
mycobactrial antigen through release of
interleukin (IL) - 10, as both LAM and IL-
10 suppress antigen-induced T cell
proliferation by interference with antigen
presenting cells function. In the present
study, the immunomodulatory effect of
M.bovis AN5 LAM and other mycobacterial
antigens on induction of interleukin (IL) - 2
was assessed.
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Veterinary Science, Veterinary Microbiology