TOXICOLOGICAL STUDIES IN THE PROGENY OF DAMS TREATED WITH METHIMAZOLE, MONOCROTOPHOS AND LEAD ACETATE
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2009-12
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
ABSTRACT :
The present study was aimed to evaluate the toxicological effects in the progeny of dams treated with methimazole, monocrotophos and lead acetate. Albino rats of Wistar Kyoto strain were divided into 5 groups and treated as follows: Group 1 served as sham control, 2 received methimazole, 3 received monocrotophos, 4 received lead acetate and 5 received combination of monocrotophos and lead acetate.
Thyroid hormone profile was recorded on 14th day of gestation in dams. Average body weights were recorded at monthly intervals in pups born to test dams. On 21st day and 90th day, TBARS, protein carbonyls and GSH of liver and heart, histopathology of liver, heart and kidney were studied. Activity of Na+ K+ ATPase and Mg2+ATPase of liver and heart, and histopathology of brain and testis were studied on 90th day.
T3, T4, RBC, Hb, HDL cholesterol, serum calcium, GSH, Na+ K+ ATPase and Mg2+ATPase were significantly (P < 0.05) decreased in all the test groups, while TSH, TBARS, protein carbonyls, blood glucose, triglycerides, serum LDH, intra-testicular LDH, total WBC count and serum troponins were significantly (P < 0.05) increased. Group 1 did not reveal any abnormalities on histopathology. Groups 5 (MCP + lead acetate) and 2 (methimazole) showed marked congestion and degenerative changes in heart, kidney, brain and testis, while thyroid gland showed moderate disruption of follicular epithelium. Groups 3 and 4 revealed mild abnormalities on histopathology.
From this study, it is concluded that both monocrotophos and lead acetate might have a possible influence on thyroid gland of dams as the thyroid hormone levels, which play an important role in early peri-natal life in the proper development of foetus, were significantly altered and were comparable among the treatments in dams and the histological sections of thyroid obtained from progeny of MCP + lead acetate treated rats showed lesions comparable to those seen with methimazole.
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