Haemorrhagic enteritis of turkeys – current knowledge

dc.contributor.authorDhama, Kuldeep
dc.contributor.authorGowthaman, Vasudevan
dc.contributor.authorKarthik, Kumaragurubaran
dc.contributor.authorTiwari, Ruchi
dc.contributor.authorSachan, Swati
dc.contributor.authorKumar, M. Asok
dc.contributor.authorPalanivelu, M.
dc.contributor.authorMalik, Yashpal Singh
dc.contributor.authorSingh, Raj Kumar
dc.contributor.authorMunir, Muhammad
dc.contributor.authorTANUVAS
dc.date.accessioned2018-07-13T12:04:51Z
dc.date.available2018-07-13T12:04:51Z
dc.date.issued2017
dc.descriptionTNV_VQ_2017_37(1)31-42en_US
dc.description.abstractHaemorrhagic enteritis virus (HEV), an adenovirus associated with acute haemorrhagic gastrointestinal disease of 6–11-week old turkeys predominantly hampers both humoral and cellular immunity. Affected birds are more prone to secondary complications (e.g. colibacillosis and clostridiosis) and failure to mount an effective vaccine-induced immune response. HEV belongs to the new genus Siadenovirus. Feco-oral transmission is the main route of entry of the virus and it mainly colonizes bursa, intestine and spleen. Both naturally occurring virulent and avirulent strains of HEVs are serologically indistinguishable. Recent findings revealed that ORF1, E3 and fib genes are the key factors affecting virulence. The adoption of suitable diagnostic tools, proper vaccination and biosecurity measures have restrained the occurrence of disease epidemics. For diagnostic purposes, the best source of HEV is either intestinal contents or samples from spleen. For rapid detection highly sensitive and specific tests such as quantitative real-time PCR based on Taq man probe has been designed. Avirulent strains of HEV or MSDV can be effectively used as live vaccines. Novel vaccines include recombinant hexon proteinbased subunit vaccines or recombinant virus-vectored vaccines using fowl poxvirus (FPV) expressing the native hexon of HEV. Notably, subunit vaccines and recombinant virus vectored vaccines altogether offer high protection against challenge or field viruses. Herein, we converse a comprehensive analysis of the HEV genetics, disease pathobiology, advancements in diagnosis and vaccination along with appropriate prevention and control strategies.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810060154
dc.keywordsTurkey; haemorrhagic enteritis virus; pathobiology; diagnosis; vaccine; control; reviewen_US
dc.language.isoenen_US
dc.pages31-42en_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofseries;1
dc.subjectven_US
dc.titleHaemorrhagic enteritis of turkeys – current knowledgeen_US
dc.title.alternativeVeterinary Quarterlyen_US
dc.typeArticleen_US
dc.volume37en_US
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