Chemoprofiling, biochemical and pharmacological screening of various fennel (Foeniculum vulgare Mill.) genotypes
| dc.contributor.advisor | Viveka Nand | |
| dc.contributor.author | Mehra, Nisha | |
| dc.date.accessioned | 2021-09-30T06:41:45Z | |
| dc.date.available | 2021-09-30T06:41:45Z | |
| dc.date.issued | 2021-02 | |
| dc.description.abstract | The present study deals with the investigation of 11 fennel (Foeniculum vulgare Mill.) genotypes were evaluated for theirchemical composition, phytochemical assays, nutritional profiling, pharmacological attributes and biological activity. GC-MS analysis in hexane and methanolic extract demonstrated the identification of various phytoconstituents representing 70.79-100% of the total extract. A higher percentage of phytoconstituents was observed in methanolic extract of FNL-PM (100%). Various fatty acids and fatty esters were identified as dominant constituents in addition to minor components. Total phenolic content in hexane, chloroform and methanol extract were ranged (1.43±0.40 to 7.10±0.51), (1.34±0.39 to 0.76±0.01) and (4.78±1.56 to 32.90±0.79) mg GAEg-1. Flavonoid content ranged in hexane extract (0.57±0.26to2.98±0.65),in chloroform extract (0.40±0.19 to 1.95±0.35)and methanol extract (0.57±0.13 to 11.92±1.86)mg CAEg-1.Orthodihydric amount in hexane extract is (1.36±0.14-31.to 75±0.08), in chloroform extract (1.34±0.35 to 49.41±4.3) and methanol extract (22.46±0.26 to 59.57±0.30) mg CLEg-1. Proanthocyanidine content in hexane extracts (0.55±0.24 to 15.59±0.28),in chloroform extract (0.88±0.55 to 22.42±0.21)in methanol extract (10.47±0.17 to 33.62±0.34)mg CAEg- 1. In hexane extract, total tannins content (3.01±0.10 to 5.52±0.07), in chloroform extract (1.03±0.03 to 7.47±0.32)and methanol extract (3.67±0.22 to 8.42±0.32) mg TAEg- 1.Maximum DPPH scavenging activity exhibited in the hexane extract of FNL-PM (IC 50 = 443.88±0.91 μg/ml). Maximum hydroxyl radical scavenging in methanol extract of FNL-117 (IC50=414.74±1.35 μg/ml). High superoxide radical scavenging in the hexane extract of FNL-126 (IC50=420.68±1.09 μg/ml). Maximum nitric oxide radical scavenging potential found in hexane extract of FNL-117 (IC50=557.03±0.86 μg/ml). Strong chelation observed in hexane extract of FNL-118 (IC50=563.07±0.07 μg/ml). The highest FRAP activity observed in the methanol extract of FNL-126 (8.08±0.008 μ mole/g). All fennel genotypes were observed to be effective against bacterial strains in a dose dependent manner while FNL-117 have no inhibitory action against any bacteria. Maximum α-amylase observed in the hexane extract of FNL-125 (IC50=227.77±0.64 μg/ml) and high α-glucosidase activity in the hexane extract of FNL-120 (IC50=230.02±0.62 μg/ml). Higher anti-inflammatory potential observed in the hexane extract of FNL-124 (IB50=663.22±1.98 μg/ml). Proximate analysis in terms of ash, moisture, crude fat, crude fibre, total protein and carbohydrate content showed a rich nutritional value in fennel genotypes. The macro and micro-nutrient were observed in order Ca> K> Mg>Fe> Na> Ni>Cu>Mn>Cr>Co. Fennel genotypes demonstrated moderate herbicidal potential. | en_US |
| dc.identifier.uri | https://krishikosh.egranth.ac.in/handle/1/5810176456 | |
| dc.keywords | chemoprofiling, biochemistry, pharmacology, screening, Foeniculum vulgare, genotypes | en_US |
| dc.language.iso | English | en_US |
| dc.pages | 283 | en_US |
| dc.publisher | G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand) | en_US |
| dc.research.problem | Foeniculum vulgare | en_US |
| dc.sub | Chemistry | en_US |
| dc.theme | Biochemistry | en_US |
| dc.these.type | Ph.D | en_US |
| dc.title | Chemoprofiling, biochemical and pharmacological screening of various fennel (Foeniculum vulgare Mill.) genotypes | en_US |
| dc.type | Thesis | en_US |