Toxic effects induced by Bisphenol A in male albino rats
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Date
2022
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Punjab Agricultural University
Abstract
Bisphenol A (BPA) is a xenoestrogen which acts as an endocrine disrupting chemical, found ubiquitously in the environment. The present study was carried out to examine the toxicological effects of BPA in male albino rats by keeping in view the continuous exposure of this chemical to the living organisms. The rats were divided into four groups (n=6) with group I as control and group II, III and IV administered with BPA orally @ 0.25, 2.5 and 25 mg/Kg b.wt. of BPA, respectively for a period of 30 days. BPA treated rats did not show any change in behaviour and body weight with respect to control rats. The weight of organs i.e. kidney, testis, epididymis and liver showed significant change in group IV rats as compared to other groups. The activity of antioxidant enzymes (SOD, CAT, GPx, GR, GST) in liver, kidney, testis and epididymis of albino rats decreased significantly along with simultaneous increase in MDA levels with increasing dose of BPA. The protein, lipid and phospholipid
content decreased whereas cholesterol level increased significantly in different organs of group III and IV rats in a dose dependent manner. Histological slides showed damaged irregular boundaries of seminiferous tubules along with interstitium widening and sloughing off of germinal epithelium. Abnormalities and loss of circular shape of tubules were observed in cauda epididymis. Intense immunohistochemical reaction indicating comparatively high expression of ER-β receptor in the nuclei of spermatogonia, peritubular myoid cells and leydig cells of the testis and in the epithelial and stromal cells of the cauda epididymis.
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Sharma, Prachi (2022), Toxic effects induced by Bisphenol A in male albino rats (Unpublished M.Sc. thesis). Punjab Agricultural University, Ludhiana, Punjab, India.