Ameliorative potential of Vitamin C against Bisphenol A induced alterations in reproduction of male albino rats
Loading...
Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Punjab Agricultural University, Ludhiana
Abstract
Bisphenol A (BPA), has been overused worldwide and acts as an endocrine disruptor
generating genotoxic and cytotoxic effects in male reproductive system by disturbing cellular
antioxidant balance causing oxidative stress. Hence, this study focussed on amelioration of
BPA induced toxicity by supplementing Vitamin C. Rats were treated for 45 days with 20
mg/kg b.w. BPA, 20 mg/kg b.w. BPA+40, 80, 120 and 160 mg/kg b.w. Vitamin C. BPA
gavaged rats showed hyperactivity, irritability, wounds and weakness and no such symptoms
were seen in other groups. BPA significantly decreased body weight and organ weight of
reproductive organs as compared to control but were significantly increased in Vitamin C
groups. Histological alterations like tubular distortions and widening of interstitium were
observed in testis and cauda epididymis of rats treated with BPA alone. Sperm motility,
viability and count significantly decreased in BPA group with increase in sperm abnormalities
whereas Vitamin C reversed BPA caused changes. BPA significantly decreased plasma levels
of FSH, LH and Testosterone and increased Estrogen while Vitamin C significantly increased
FSH, LH and Testosterone and significantly decreased Estrogen. SOD, CAT, GR, GPx, GST,
total lipids and phospholipids decreased in testis and epididymis of BPA rats and increased at
different doses of Vitamin C. BPA significantly increased LPO and cholesterol but Vitamin C
decreased them in dose dependent manner.
Description
Keywords
Citation
Nimrat Kaur (2021). Ameliorative potential of Vitamin C against Bisphenol A induced alterations in reproduction of male albino rats (Unpublished M.Sc. thesis). Punjab Agricultural University, Ludhiana, Punjab, India.