STUDY ON INCIDENCE OF MAMMARY TISSUE CARCINOGENESIS IN CONJUGATED LINOLEIC ACID FED FEMALE WISTER RATS.
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Date
2016
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Abstract
A study was carried out to investigate anti carcinogeneic effect of Conjugated linoleic acid (CLA) feeding on mammary gland carcinogenesis in rats. Female wistar rats of 21 day’s old were taken for the study and animals were randomly divided into 2 groups of thirty animals in each group. In group I, animals were fed with soybean oil based diet where as group II animals were fed with CLA ghee based diet, respectively. Soybean oil and CLA ghee were included at 10 per cent level in the animal diet. Feeding of test diets were started on the day of weaning. Animals were given 7, 12 dimethyl benz (a) anthracene (DMBA) at 5 mg per animal as single dose by oral intubation at the age of 55th day and test diets were continued upto 32 weeks after DMBA administration. At the end of 32 weeks, all animals were sacrificed, tumour data recorded and histopathology done. Tumour incidence in group I and III were 83.33 and 46.07 per cent respectively. Histopathology revealed fibroma, adenoma, fibro adenoma in all the groups whereas in group I showed adenocarcinoma. Therefore, results of present study showed the conjugated linoleic acid not only inhibited benign type tumour but malignant tumour as well.
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TNV_JCTR_2016_16(3)5629-5632
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Veterinary Science