Efficacy of Bacterial Collagenase Therapy in RFM Cows Assesed through Concentration of Serum and Lochial NAGase
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Date
2018-10
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Abstract
The study was conducted in cases of RFM presented within 12 to 24 hours after parturition
to Obstetrics Unit of Madras Veterinary College, Chennai. Group I received placebo
treatment with one litre of normal saline intravenously. Group II cows, treated with
intrauterine proteolytic bolus containing nitrofurazone, metronidazole and urea and
antibiotic therapy (Inj. Streptopenicillin @ 20,000 units/kg body weight) without manual
removal for 7 days. Groups III cows, received single dose of 2, 00,000 CDU of
collagenase plus 40 mg of calcium chloride and 40 mg of sodium bicarbonate dissolved in
one litre of normal saline at a pH of 7.5 intravenously through jugular vein (Eiler and
Hopkins, 1993). Group IV received single dose of 2,00,000 U of collagenase
intravenously. The data on the concentration of serum and lochial NAGase of all the
different treatment groups with serum and lochia samples were collected. Further,
collected data were compared and analyzed; which showed that the serum NAGase
concentration was significantly (P<0.01) higher in group IV on day 0; group II on day 7;
group II and IV on day 14; and the overall mean concentration was significantly (P<0.05)
lower in groups I and III. The lochial NAGase concentration was significantly (P<0.05)
higher in group IV on day 0 and group II on day 7 and 14. These results revealed that the
administration of collagenase through intravenous route had achieved better healing and
recovery.
Description
TNV_IJCMAS_2018_7(10)769-776
Keywords
Veterinary Science