STUDIES ON PATHOGENESIS OF PASTEUEELLA INFECTION IN CORTISONE-TREATED, IMMUNIZED, SUSCEPTIBLE AND CONTROL RABBITS
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Date
1998
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DUVASU
Abstract
IT IS NOT KNOWN whether possession of
specific antibody provides any immunity
against cryptococcal infection. Diamond
and Allison (1976) demonstrated antibodydependent
killing of C. neoformans by
human peripheral-blood mononuclear cells
in vitro, suggesting that antibody might
play a role in host defence against cryptococci.
Gadebusch (1958) showed limited
protection when antiserum was injected
i.p. with cryptococci in mice. Also,
clinical observations in humans with
cryptococcal meningitis suggest that the
outcome is more likely to be favourable in
patients with measurable titres of serum
antibody (Diamond and Bennett, 1974).
Specific anti-cryptococcal immuno-globulin
has been detected in the cerebrospinal
fluid (CSF) of a patient with cryptococcal
meningitis (Porter, Sinnamon and Gillies,
1977). On the other hand, passive immunization
of mice conferred no detectable
protection against challenge with these
yeasts (Louria and Kaminski, 1965;
Goren, 1967). Mice with a genetically
determined B-cell deficiency are not more
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