PHARMACOKINETIC STUDIES OF METRONIDAZOLE IN COW CALVES AFTER INTRAVENOUS AND ORAL ADMINISTRATION
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Date
1991
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AAU, Anand
Abstract
In the present study, pharmacokinetics and dosage of metronidazole were determined in cow calves following single intravenous (20 mg/kg body weight) and oral (20 and 50 mg/kg body weight) administration. As compared to intravenous administration lower levels of metronidazole were estimated in plasma following oral adminis tration . The therapeutic plasma concentration of metronidazole was maintained upto 6 h following intravenous administration. Whereas after oral administration at dosage levels of 20 and 50 mg/kg body weight, it was maintained for 3 and 10 h, respectively, The pharmacokinetics of metronidazole after intravenous administration was best described by a two-compartment open model, following intravenous administration, the distribution and elimination half lives , volume of distribution and total body clearance were 0.07 ± 0.01 h, 1.92 ± 0.05 h, 0.79 ± 0.03 1.kg-1 and 283.49 ± 6.15ml. h-1. kg-1 respectively.
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VETERINARY PHARMACOLOGY, A STUDY