PHARMACOKINETIC STUDIES OF METRONIDAZOLE IN COW CALVES AFTER INTRAVENOUS AND ORAL ADMINISTRATION

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dc.contributor.advisorMalik, J. K.
dc.contributor.authorBHAVSAR, S. K.
dc.date.accessioned2018-06-07T10:14:22Z
dc.date.available2018-06-07T10:14:22Z
dc.date.issued1991
dc.description.abstractIn the present study, pharmacokinetics and dosage of metronidazole were determined in cow calves following single intravenous (20 mg/kg body weight) and oral (20 and 50 mg/kg body weight) administration. As compared to intravenous administration lower levels of metronidazole were estimated in plasma following oral adminis tration . The therapeutic plasma concentration of metronidazole was maintained upto 6 h following intravenous administration. Whereas after oral administration at dosage levels of 20 and 50 mg/kg body weight, it was maintained for 3 and 10 h, respectively, The pharmacokinetics of metronidazole after intravenous administration was best described by a two-compartment open model, following intravenous administration, the distribution and elimination half lives , volume of distribution and total body clearance were 0.07 ± 0.01 h, 1.92 ± 0.05 h, 0.79 ± 0.03 1.kg-1 and 283.49 ± 6.15ml. h-1. kg-1 respectively.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810049911
dc.keywordsPHARMACOKINETIC STUDIES OF METRONIDAZOLE, COW CALVES AFTER INTRAVENOUS, ORAL ADMINISTRATIONen_US
dc.language.isoenen_US
dc.publisherAAU, Ananden_US
dc.research.problemPHARMACOKINETIC STUDIES OF METRONIDAZOLE IN COW CALVES AFTER INTRAVENOUS AND ORAL ADMINISTRATIONen_US
dc.subVeterinary Pharmacologyen_US
dc.subjectVETERINARY PHARMACOLOGYen_US
dc.subjectA STUDYen_US
dc.themePHARMACOKINETIC STUDIES OF METRONIDAZOLE IN COW CALVES AFTER INTRAVENOUS AND ORAL ADMINISTRATIONen_US
dc.these.typeM.V.Sc.en_US
dc.titlePHARMACOKINETIC STUDIES OF METRONIDAZOLE IN COW CALVES AFTER INTRAVENOUS AND ORAL ADMINISTRATIONen_US
dc.typeThesisen_US
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