Age Related Changes in T Cell Subsets in Thymus and Spleen of Layer Chicken (Gallus domesticus)
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Int. J. Curr. Microbiology and Applied Sciences
Abstract
Flowcytometric analysis of T lymphocyte subset viz., CD and CD8 cells in spleen and
thymus was done in Nandanam layer chicken of different age groups ranging from day-old
to forty weeks. . In spleen, the mean CD4 and CD8 population was found to be the highest
at day one and lowest at twenty weeks of age. However, an increase in both the T cell
population was detected at forty weeks. Among the two cell types studied, CD8 cells were
always higher than the CD4 cells, with significant difference (P<0.05) at day one. The
distribution pattern of CD4 and CD8 cells in thymus was slightly different from that of
spleen. Thymus had more CD4 cells on day one followed with twelve weeks of age. In
contrast, CD8 cells were more on twelve weeks followed with day one. The CD4 and CD8
cell populations were lowest in four weeks of age. A distinct difference was observed in
the ratio of CD4 and CD8 cells in the spleen and thymus at different age. At day one the
ratio was less in spleen and high in the thymus. However, at eight weeks of age, CD4 cell
ratio was high in spleen and low in thymus. Nevertheless, the ratio narrowed down at forty
weeks of age.
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Keywords
Veterinary Science