CLINICO-THERAPEUTIC STUDIES ON TRYPANOSOMOSIS IN BUFFALOES IN CERTAIN PARTS OF ANDHRA PRADESH
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Date
2011-10
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI – 517 502. (A.P) INDIA
Abstract
ABSTRACT:
The present study was undertaken to study the prevalence, clinical symptoms , haemato biochemical changes and therapeutic regimen of trypanosomosis in buffaloes in and around Krishna District during December 2010 to August 2011. Out of 480 suspected buffaloes by wet film, buffy coat and Leishmans smear the prevalence was found to be 9.38 per cent. Highest prevalence was recorded during the month of December due to high vector population.Trypanosomosis affected buffaloes exhibited general symptoms like intermittent fever, weakness, gradual loss of condition, reduced appetite, drop in milk yield in lactating animals, congestion of conjunctival mucosa, swelling of throat, head pressing /circling and abortions in pregnant animals.There was significantly decrease (P<0.01) in packed cell volume, haemoglobin and total erythrocyte count when compared to healthy control.Biochemical profile in trypanosomosis affected buffaloes revealed significantly by (P<0.01) reduction in serum glucose, total serum protein and increase in bilirubin compared to healthy control group.Clinico – haematological and biochemical studies were also conducted before and after therapy with Isometamidium chloride, Diminazine aceturate and Quinapyramine sulphate and chloride. For therapeutic studies 45 trypanosomosis positive buffaloes were selected and randomly divided into three groups (Group I, II and
III) with 15 animals in each group. Fifteen apparently healthy buffaloes served as healthy control (Group – IV).
Buffaloes in Group – I were treated with isometamidium chloride single I/M injection @ 0.5 mg/kg.b.wt. Group-II, buffaloes were treated with diminazine aceturate deep I/M injection @ 8.0 mg/kg b.wt, while in Group – III buffaloes were administered with quinapyramine sulphate and chloride S/C @ 4.4 mg/kg b.wt. in a single dose.Inj.Tribivet, 25% dextrose and an anti-inflammatory drug inj. Melonex were given to all the three groups uniformly as supportive therapy.The efficacy of each drug was judged on the basis of period required for disappearance of parasites, clinical recovery and improvement in haematobiochemical parameters and occurrence of relapses following medication. Therapeutic evaluation at a glance revealed that buffaloes treated with isometamidium chloride, diminazine aceturate and quinapyramine sulphate and chloride recovered in a mean period of 6.50 ± 0.64; 8.50 ± 0.64 and 5.66 ± 0.33 days respectively. Hence use of quinapyramine sulphate and chloride and isometamidium chloride is recommended to treat this disease under field conditions.
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