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Birsa Agricultural University, Ranchi

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20121
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Subject: Veterinary Microbiology × Author: Kumari, Meera × Start date: 2010 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON COMPARATIVE EFFICACY AND SAFETY OF MEGAVAC-6 WITH VANGUARD 5L AND NOBIVAC DHPPI FOR PARVOVIRUS IMMUNIZATION
    (Birsa Agricultural University, Kanke, Ranchi, Jharkhand, 2012) Kumari, Meera; Prasad, Arun
    The present study on the topic “Studies on comparative efficacy and safety of Megavac 6 with Vanguard 5L and Nobivac DHPPI for parvovirus immunization” was carried out to eliciting immune response in pups against parvovirus infection. For this purpose 24 unvaccinated healthy puppies (Non descript), 8-18 wks were enrolled and divided into four groups. Each contained 6 pups. GrpI received Megavac 6, grpII received Vanguard 5 L, grpIII received Nobivac DHPPI and grp IV was taken as control. To determine efficacy of vaccines estimation of maternal antibody was observed by HI and SNT as per Buxton and Frazer 1997 on 0th day prior to administration of vaccine and data was compared with titres obtained on 28th day and 35th day. The pups carried a detectable level of maternal antibody on 0th day not showed any significant difference between different groups. After vaccination on day 28th and 35th Megavac 6 treated groups showed highly significant (p<0.01) MHI and SNT antibody titre than Vanguard 5L treated group and Nobivac DHPPI treated groups. Control group i.e. grp IV showed significant decrease in HI and SNT antibody titre. No unusual symptoms were noted. Non of the group showed any adverse reaction during and after vaccination. Based on the findings of the trial, following conclusion can be drawn. Megavac 6, Vanguard 5L & Nobivac DHPPI can be used to protect dogs against parvovirus infection. Efficacy of Megavac 6 was better than vanguard5L & Nobivac DHPPI & was more active during maternal antibody interference. Megavac 6, Vanguard 5L &Nobivac DHPPI were safe & did not show any adverse reaction during &after vaccination. The health status of the pups vaccinated with Megavac 6 Vanguard 5L & Nobivac DHHPI were sound and better in comparison to unvaccinated animals.