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Chaudhary Sarwan Kumar Himachal Pradesh Agriculture University, Palampur

Himachal Pradesh Krishi Vishvavidyalaya (renamed as Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya in June, 2001) was established on 1st November, 1978.The College of Agriculture (established in May, 1966) formed the nucleus of the new farm University. It is ICAR accredited and ISO 9001:2015 certified institution. The Indian Council of Agricultural Research has ranked this University at eleventh place among all farm universities of the country. The University has been given the mandate for making provision for imparting education in agriculture and other allied branches of learning, furthering the advancement of learning and prosecution of research and undertaking extension of such sciences, especially to the rural people of Himachal Pradesh. Over the years, this University has contributed significantly in transforming the farm scenario of Himachal Pradesh. It has developed human resources, varieties and technologies and transferred these to farming community enabling the State to receive the “Krishikarman award” of Govt. of India four times in row for food grain production among small states of the country. Today, the State has earned its name for hill agricultural diversification and the farming community has imposed its faith in the University.

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Subject: Veterinary Pharmacology and Toxicology × Author: Tandon, Tamanna × Start date: 2014 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    BIOENHANCING EFFECT OF BERBERIS ARISTATA AND CURCUMA LONGA ON PHARMACOKINETICS OF AMOXICILLIN IN CALVES
    (CSKHPKV, Palampur, 2014-07) Tandon, Tamanna; Varshneya, C.
    The bioenhancing effects of Berberis aristata and Curcuma longa (30 mg.kg-1) were studied on pharmacokinetics of amoxicillin in calves. The studies were carried out on six apparently healthy male calves (2-3 months of age). The calves were divided into six groups and amoxicillin was administered at the dose rate of 10 mg.kg-1 by intravenous and oral route in groups I and II, respectively. The animals of group III and IV received extracts of Berberis aristata and Curcuma longa along with amoxicillin, respectively. The animals of group V and VI received only the extracts of Berberis aristata and Curcuma longa, respectively. The blood samples were collected at 2.5 min., 5 min., 10 min., 15 min., 30 min., 1h, 2 h, 4 h, 6 h, 8 h, 10 h and 12 h following the intravenous administration and samples were collected at 15 min., 30 min., 1h, 2 h, 3 h, 4 h, 5 h, 6 h, 8 h, 10 h and 12 h after oral administration. The samples were analysed for amoxicillin using agar plate diffusion method. The disposition kinetics of amoxicillin followed two compartment open model following intravenous and oral administration. Following a single intravenous injection of amoxicillin, the plasma level was 11.9 ± 0.21 μg.ml-1 at 2.5 min. and the drug was detected above MIC in plasma upto 6 h. The pharmacokinetic parameters of the distribution and elimination phase of amoxicillin revealed rapid distribution of the drug into body fluids and tissues with a short distribution half life of 0.13 ± 0.01 h. A fair distribution of drug was also reflected by the high values of K12/K21 ratio (1.81 ± 0.05) and AUC (16.13 ± 0.28 μg.ml-1.h). The values of t1/2β, Kel, ClB and MRT were: 2.50 ± 0.07 h, 0.88 ± 0.01h-1, 620.75 ± 10.49 ml.kg-1.h-1 and 3.18 ± 0.08 h, respectively. After oral administration the peak plasma level was achieved at 3 h and the values of AUC, t1/2β, ClB and MRT were: 9.25 ± 0.31 μg.ml-1.h, 1.66 ± 0.05 h, 617.03 ± 10.71 ml.kg-1.h-1 and 3.79 ± 0.06 h, respectively. The simultaneous administration of extracts of Berberis aristata and Curcuma longa altered both the absorption and elimination phases. The findings of the present study revealed that amoxicillin has a bioavailability of 57 percent. The simultaneous administration of extracts significantly (P<0.05) increased the oral bioavailability of amoxicillin.