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Chaudhary Sarwan Kumar Himachal Pradesh Agriculture University, Palampur

Himachal Pradesh Krishi Vishvavidyalaya (renamed as Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya in June, 2001) was established on 1st November, 1978.The College of Agriculture (established in May, 1966) formed the nucleus of the new farm University. It is ICAR accredited and ISO 9001:2015 certified institution. The Indian Council of Agricultural Research has ranked this University at eleventh place among all farm universities of the country. The University has been given the mandate for making provision for imparting education in agriculture and other allied branches of learning, furthering the advancement of learning and prosecution of research and undertaking extension of such sciences, especially to the rural people of Himachal Pradesh. Over the years, this University has contributed significantly in transforming the farm scenario of Himachal Pradesh. It has developed human resources, varieties and technologies and transferred these to farming community enabling the State to receive the “Krishikarman award” of Govt. of India four times in row for food grain production among small states of the country. Today, the State has earned its name for hill agricultural diversification and the farming community has imposed its faith in the University.

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2012 - 20162
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Subject: Veterinary Microbiology × Author: Katoch, Shailja × Start date: 2005 × Type: Thesis ×
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    ThesisItemOpen Access
    Studies on the pathogenic potential of pasteurella multocida harbouring different ompa
    (CSKHPKV, Palampur, 2012) Katoch, Shailja; Sharma, Mandeep
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    ThesisItemOpen Access
    CELLULAR, IMMUNOLOGICAL AND MOLECULAR RESPONSES AGAINST PASTEURELLA MULTOCIDA IN CALVES
    (CSKHPKV, Palampur, 2016-01-23) Katoch, Shailja; Sharma, Mandeep
    ABSTRACT The present study determined the cellular, molecular and immunological responses following P. multocida infection and vaccination in calves. Four months old nine clinically healthy male cross bred calves were divided into three groups. Calves in vaccinated group were immunized with 2 ml commercial formalin killed alum adjuvant HS vaccine s/c, infected group challenged i/n with 5ml of the inoculum containing 3×109 cfu/ml/nostril of P. multocida B:2 and control group was given 5 ml PBS i/n/nostril. The clinical observations were monitored and serum, nasal secretions and whole blood samples were collected. The mean rectal temperature and mean total clinical score of the infected group was significantly higher than other groups from day 3 to 8 and day 2 to 20, respectively. The serum IgG and IgM response and IgA response in nasal secretions in the infected group was significantly higher than vaccinated group. The CD3+, CD4+, CD8+, CD3+CD4+ and CD3+CD8+ T cells increased in both vaccinated and infected group, however the increase was significant only in infected group. There was decrease in WC1+ and CD3+WC1+ T cells initially in vaccinated and infected group and then it significantly increased. The WC1+ T cells were more in vaccinated group compared to infected group. In vaccinated and infected groups, both Th1 and Th2 type of immune responses played important role in initiation of immune response, but, in infected group Th2 response dominated. In vaccinated group Th1 response was more as compared to infected group. The production of IFNγ in both the groups suggests the role of cell mediated immunity in the development of immune response. Thus, both humoral and cell mediated immune responses are elicited against live P. multocida intranasal challenge and formalin killed alum adjuvant vaccine. The live bacteria induce more robust local secretory IgA antibody response compared to killed bacteria in vaccine which lead to clearing of bacteria in infected group