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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Osteosynthesis in induced tibial segmental defect using co-precipitated hydroxyapatite gel and titanium mesh cage in rabbits (Oryctolagus cuniculus)
    (G. B. Pant University of Agriculture and Technology, Pantnagar, 2022-09) Karki, Nikita; Karki, Nikita; Das, Arup Kumar; Das, Arup Kumar
    The present study was conducted in (12) clinically healthy adult New Zealand white rabbits (1.5-2.0 years old), of either sex weighing 1.5-2.0 kg and they were subjected to induction of segmental defect in tibia under general anaesthesia. Thereafter, insertion of intramedullary titanium pin along with cylindrical titanium mesh cage and injectable co-precipitated HA gel used for reconstruction of segmental defect in tibia. All rabbits were divided randomly in two groups (A and B) with 6 animals in each group. In rabbits of Group A fracture fragments were stabilized with titanium mesh and titanium screws. While in rabbits of Group B, fracture fragments were stabilized with titanium mesh cage, reinforced with intramedullary pin and injectable co- precipitated HA ladened Mg-gelatin-collagen gel was used. The common features included in each rabbits of both the groups were anaesthetic regimen – premedication with glycopyrrolate, xylazine and induction of ketamine anaesthesia was pursued. Maintenance of anaesthesia was done with Isoflurane @ 1-1.5 percent concentration of with 100 percent oxygen saturation. On the basis of evaluation of parameters, better wound healing was observed in animals of Group B as compared to animals of Group A. On the basis of biochemical parameters, faster and better wound healing was observed in rabbits of Group B. Estimation of haematological and biochemical parameters were done at day 0, 7, 15, 30 and 60. There was a significant increase in serum values of ALP, calcium, phosphorus, blood glucose and decrease in magnesium, total protein. Radiological findings showed faster rate of healing and earlier reduction in gap (1.00 cm) and moderately higher radio-denser area at induced segmental defect in tibia of animals of Group B. On gross observation of test bones, negligible gap was observed at induced segmental defect in animals of Group B depicting faster healing, mineralization of developed callus and bridging of segmental defect as compared to animals of Group A. There was new bone formation found around the external circumference of the cage which was bridging the proximal and distal bone cage junction. Exuberant callus formation was found around the cage in animals of Group B. The implant remained completely stable, in correct alignment and found in pre-experimental state in animals of Group B. Titanium mesh cage used here act as scaffold for bony restoration, allows vascular supply both to the mucosa and bone during regeneration phase. The construct used here for osteosynthesis of induced segmental defect at tibia provided adequate mechanical strength, augment limb stability and early bone continuity. Conclusively a better fracture healing was observed in rabbits of Group B as compared to rabbits of Group A and it reveals that the co-precipitated HA gel used act as scaffold for bony restoration and hence it possess attributes of biodegradability, biocompatibility. The above mentioned technique can be use for treatment of long bone segmental defect as it has got wide scope to be used in clinical veterinary practice. In the present study the outcome of surgical management of large segmental defects in tibia using cylindrical titanium mesh cage was found to be effective for treatment of LBSD.
  • ThesisItemOpen Access
    Evaluation of healing efficacy of topical herbal formulations on experimental goat model
    (G. B. Pant University of Agriculture and Technology, Pantnagar, 2022-09) Ghalaut, Bharat; Das, Arup Kumar
    The present study was conducted on six male goats. Six full thickness incisional wound of 1 inch length and six excisional wounds of 1 inch × 1 inch dimension were created on both side of the back with an objective to evaluate the healing efficacy of four different topical polyherbal formulations. One positive control was treated with Soframycin ointment from day of wound creation till recovery. The other four test sites were treated with Charmil Plus gel, Charmil Spray, AV/CPS/23 lotion and Brand A respectively. One wound site was left untreated as negative control. The wounds were evaluated on the basis of clinical, macroscopical and haematobiochemical studies. Clinical and haematobiochemical parameters did not reveal any significant change between the different treatments and were variable within normal physiological limits. For clinical evaluation- quantity of exudation, wound contraction and rate of wound healing was observed. The result revealed less exudation with better healing rate and wound contraction in test product Brand A followed by Charmil spray, AV/CPS/23, and Charmil ointment in decreasing order; and all the wounds that got treatment were found to have better healing than the negative control wound
  • ThesisItemOpen Access
    Anaesthetic evaluation of various combinations of xylazine, ketamine and tiletaminezolazepam in dogs
    (G.B. Pant University of Agriculture and Technology, Pantnagar, District Udham Singh Nagar, Uttarakhand. PIN - 263145, 2022-07) Sulekha; Kandpal, Manjul
    Eighteen dogs of either sex, different breed, body weight and age (requiring various surgical corrections) were randomly divided into three groups namely A, B and C. Atropine sulphate (0.025mg/kg SC) was administered in all the groups followed by tiletamine-zolazepam (till effect IV) in group A, xylazine (0.5mg/kg IM) and tiletamine-zolazepam (till effect IV) in group B and xylazine (0.5mg/kg), ketamine (2.5mg/kg) and tiletamine-zolazepam (till effect IV) in group C. The induction dose of tiletamine-zolazepam observed in group A, B and C were 6.5, 5.5 and 4 mg/kg body weight respectively on intravenous administration. The efficacy of the anaesthesia was evaluated by observing clinical (induction dose, induction time, duration of anaesthesia, sternal recumbency time, complete recovery time, jaw relaxation score, pedal reflex score and palpebral reflex score), physiological (heart rate, respiration rate, rectal temperature, capillary refill time, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure and haemoglobin oxygen saturation), haematological (haemoglobin, total erythrocyte count, packed cell volume, total leucocyte count and differential leucocyte count) and biochemical (total protein, plasma glucose, blood urea nitrogen, serum creatinine, total bilirubin, alanine aminotransferase and aspartate aminotransferase) parameters before and after administration of anaesthetic drugs. Anaesthetic effects like analgesia and muscle relaxation was observed to be slightly better in group C in comparison to group A and B. Heart rate increased and respiration rate decreased post induction in all three groups. Haematological parameters like haemoglobin, total erythrocyte count, packed cell volume, total leucocyte count, lymphocytes, monocytes, eosinophils and basophils showed transient decrease whereas neutrophils showed transient increase in all the groups at 30 and 60 minutes post induction and approximately approached baseline value by 24 hours. Biochemical parameter like total protein showed transitory decrease whereas plasma glucose, blood urea nitrogen, serum creatinine, total bilirubin, alanine aminotransferase and aspartate aminotransferase reported an increase in all the groups at 30 and 60 minutes post induction and approached baseline values by 24 hours. These changes in haematological and biochemical parameters were within normal physiologic range. Tiletaminezolazepam with its fast and smooth induction, intermediate duration of action, excellent muscle relaxation and good compatibility with xylazine and ketamine, was found to be an effective general anaesthetic either alone or in combination. Group C with xylazine, ketamine and tiletamine-zolazepam combination required significantly lower induction dose and provided longer duration of anaesthesia in comparison to group A and group B.
  • ThesisItemOpen Access
    Studies on echostructural pattern of urinary system in adult female goats
    (G.B. Pant University of Agriculture and Technology, Pantnagar, District Udham Singh Nagar, Uttarakhand. PIN - 263145, 2022-07) Singh, Shivani; Das, Arup Kumar
    B-mode ultrasonographic study of urinary system was performed in 20 healthy adult female Jamunapari goats. Mean±S.E. values of body weight and age of selected animals were 27.49±0.79kg and 2.77+0.10 years, respectively. All twenty animals were subjected to sonographic examination after clipping the hairs from desired sites to scan the various organs of urinary system in standing position under physical restraint without using any anesthetic agent. The values of various clinico-physiological parameters including rectal temperature, heart rate, respiration rate, colour of mucous membranes were recorded to examine the health status prior to sonography. The left and right kidneys were scanned from right dorsal flank by paravertebral approach using a transcutaneous micro-convex probe at 5 MHz and a convex probe at 2.8-6 MHz frequency. A dual frequency (5-9 MHz) micro-curved array cavity probe was used to scan bladder and urethra per rectally. The renal parenchyma in healthy goats was distinctly divided into hypoechoic outer cortex and anechoic inner medulla. The hyperechoic renal sinus complex (fat, vessels, lymphatics and fibrous tissue) was present in centre of the kidney and renal pelvis was anechoic. The renal capsule was seen as hyperechoic fine line surrounding the renal parenchyma. Pulsed wave renal color doppler ultrasound was performed in 3 goats out of the 20 with the aim to generate reference images of renal vasculature in healthy goats. The mean±S.E. values of renal length, renal height, horizontal diameter of renal sinus, vertical diameter of renal sinus and diameter of renal pelvis for right kidney were 6.11±0.09, 3.26±0.08, 3.01±0.11, 1.32±0.03, 1.05±0.03, respectively while for left kidney these values were 6.02±0.09 and 3.35±0.07, 2.67±0.12, 1.14±0.06, 1.10±0.07 cm. The ureters could not be visualized in any of the goats. The distended bladder was seen as anechoic circular structure surrounded by a smooth echogenic wall with a mean thickness of 1.65+0.06 mm. No significant difference was observed in the measurements of both kidneys except in dimensions of renal sinus. Moderately positive correlation was found between renal size and body weight of goats. It was concluded that ultrasound is an easy, rapid and non-invasive method to evaluate echotexture and morphometry of structures of urinary system.
  • ThesisItemOpen Access
    Comparative evaluation of anaesthetic effects of various combinations of acepromazine, butorphanol, dexmedetomidine and ketamine in glycopyrrolate premedicated dogs maintained with Sevoflurane
    (G.B. Pant University of Agriculture and Technology, Pantnagar, District Udham Singh Nagar, Uttarakhand. PIN - 263145, 2021-02) Kundu, Saikat Kumar; Kandpal, Manjul
    Eighteen adult dogs (requiring various clinical procedures) used in this study were divided randomly into three subgroups (A, B and C). All the dogs were subjected to the administration glycopyrrolate at the dose rate of 0.01 mg/kg intramuscularly followed by acepromazine given as pre anaesthetic at the dose rate of 0.04 mg/kg IM in group A, butorphanol at the dose rate of 0.4 mg/kg IV in group B and dexmedetomidine 10 μg/kg IV in group C. Ten minutes after premedication, all the animals of each group were induced with intravenous ketamine. The induction doses were found to be 7.62±0.09 mg/kg in group A, 7.12±0.09 mg/kg in group B and 6.69±0.08 mg/kg in the animals of group C respectively. Intubation was easy and free of any major complications in the animals of group A and group C, however in the animals of group B, they showed strong coughing reflex, chewing motion and strong tongue with-drawl during the time of intubation. Anaesthesia was maintained in all the groups of animals with sevoflurane. The minimum concentration of inhaled sevoflurane for maintenance of anaesthesia was noted in all the animals by the tail clamp method. The level of anaesthesia was determined by observing various clinical (Induction time, intubation score, duration of anaesthesia, muscle relaxation, pedal reflex, recovery time, complete recovery time, recovery score, required doses of different drugs and minimum concentration of inhaled sevoflurane, physiological (rectal temperature, heart rate, respiration rate, blood pressure, capillary refill time, haemoglobin oxygen saturation-SpO2, electrocardiography), haematological (haemoglobin, total erythrocyte count, erythrocyte sedimentation rate, total leucocyte count, differential leucocyte count, packed cell volume, and biochemical (serum glucose, total protein, serum urea nitrogen, serum creatinine, alanine amino transferase ,aspartate amino transferase and total bilirubin) parameters. The animals of group C showed quicker induction. All anaesthetic combinations tested in the study were able to provide adequate muscle relaxation but group C showed better result. The pedal reflex was totally lost after administration of the induction agents in all the groups. The recovery time, complete recovery time were highest in group B followed by group C and group A. The minimum concentration of inhaled sevoflurane for maintenance of anaesthesia were found to be (1.68 ± 0.47)% for group A, (2.00 ± 0.25)% for group B and (1.85 ± 0.54)% for group C. The rectal temperature, heart rate and respiration rate showed significant decrease at various time intervals. The systolic, diastolic and mean arterial pressures showed significant decrease in its values in the groups A but not in the group B and group C, and returned to their base values by 90 minutes post anaesthesia. In all the groups of animals the capillary refill time (CRT) and haemoglobin oxygen saturation (SpO2) were always less than 2 seconds and more than 95% respectively. The haemoglobin, PCV, TLC and TEC values of the animals in various groups showed significant decrease in its values whereas the ESR showed a significant increase. Significant changes were observed in differential leucocyte count. Serum glucose, Serum urea nitrogen, creatinine, ALT, AST and total bilirubin levels increased significantly in all the groups of animals however there was significant decrease in total protein levels. On the basis of above mentioned parameters, it was concluded that the most efficacious anaesthetic combination was glycopyrrolate (0.01 mg/kg IM) dexmedetomidine (10 μg/kg IV)- ketamine (6.69±0.08 mg/kg IV) and sevoflurane (1.85 ± 0.54) % in the animals of group C and it was found suitable for surgeries because of its smooth induction, less induction time, excellent muscle relaxation and analgesia properties, maximum dose sparing effect on ketamine and smooth and uneventful recovery.
  • ThesisItemOpen Access
    Clinical and radiographic study on surgical management of distal diaphyseal fracture in long bones by end threaded positive profile intramedullary pins and titanium elastic nails in dogs
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2021-08) Manish Kumar; Kandpal, Manjul
    The present study was conducted on 12 clinical cases of dogs of either sex with distal diaphyseal long bone fractures. The animals were randomly divided into two groups having equal numbers viz. Group A in which the fracture was stabilized with End threaded positive profile intramedullary pins and Group B by Titanium elastic nails. Diagnosis of the distal diaphyseal fracture done by preoperative clinical evaluation and radiography. Various parameters like clinic-physiological parameters like rectal temperature, heart rate, respiration rate, inflammation, pain score, lameness and weight bearing score, Haematobiochemical parameters like Hb, TEC, TLC,DLC & ALP were recorded in all the animals at various time interval. Clinico-physiological parameters did not show any significant difference between the both groups and were fluctuating within normal physiological range. Intra operative observation like duration of surgery, radiation exposure time, extent of manipulation and soft tissue damage, degree of technical difficulties, status of fracture reduction and fracture fixation was also recorded. The mean duration of surgery and intraoperative radiation exposure time significantly less in Group A compare to Group B. Lameness score was significantly less in group B compare to group A. The weight bearing score was significantly more in Group B as compare to Group A. Post-operative radiograph revealed intact implants with evidence of significant bridging callus and better radiographic healing grade in Group B as compare to Group A. Functional outcome score was significantly more in Group B as compare to Group A. The post-operative complication comprised of loosening and distal migration of pin in one case of Group A. The haematobiochemical parameters were within the physiological range and change in the mean values between the groups were statistically non-significant. For the physiological and anatomical repair of the fracture site, the titanium elastic nailing was found to be superior method than End threaded positive profile intramedullary pinning.Titanium elastic nailing resulted in early weight bearing and limb use along with better ability to withstand the stresses of weight bearing.
  • ThesisItemOpen Access
    Studies on the diagnosis and management of corneal ulcer in dogs
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2021-05) Kaushal, Sara; Jadon, N.S.
    Twenty four dogs of either sex for the treatment of corneal ulcers were used in this study. The animals were randomly divided into three groups having equal number of animals viz. group I treated with medicinal therapy, group II treated with membranoplasty and medicinal therapy and group III, treated by application of contact lens along with tarsorrhaphy and medicinal therapy. The diagnosis was made on the basis of detailed ophthalmic examination and various diagnostic tests such as vision reflex tests, Schirmer’s tear test, fluorescein dye test, microbiological sampling, ophthalmoscopic examination and tonometry on the day of presentation and on the day of suture removal. Besides this, various clinical, haematological (Hb, TEC, PCV, TLC and DLC) and biochemical (serum glucose, total protein, serum albumin and serum globulin) parameters were studied at 0, 1st, 2nd, 3rd, and 4th week using standard protocols. On the basis of parameters observed in this study, it was concluded that the clinical parameters did not reveal any significant change between the different treatment groups and were fluctuating within the normal physiological limits. Macroscopically, conjunctival infection and chemosis, corneal edema, transparency, decreased tear production, fluorescein dye uptake, pupillary and blink reflexes and neovascularisation were observed on the corneal wounds of different groups. The results suggested that early corneal healing with maximum reduction in conjunctival infection, edema, neovascularization was observed in the animals of group III, followed by groups II and I. It was concluded that medicinal treatment, which included eye ointment (neosporin: neomycin, bacitracin and polymyxin B), anti-inflammatory agent (carprofen), systemic broad-spectrum antibiotic (doxycycline) and carboxymethyl cellulose eye drops (refresh tears) was found to be effective in uncomplicated, superficial ulcers. However, many complications such as epiphora, keratitis, corneal scarring and edema were observed. Membranoplasty/third eyelid flap technique with medicinal treatment in animals of group II, resulted in effective healing of the corneal ulcer as compared to the animals of group I. Complications including flap dehiscence, edema and scarring were observed. Application of contact lens along with tarsorrhaphy and medicinal treatment in group III was found to be most efficacious for the management of corneal ulcers, as minimal postoperative complications were observed in this group, along with faster recovery and earlier restoration of vision as compared to the other two treatment groups.
  • ThesisItemOpen Access
    Evaluation of propofol and ketamine total intravenous anaesthesia in midazolambutorphanol premedicated goats with or without dexmedetomidine
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2020-09) Negi, Bharti; Bodh, Deepti
    In the present study twenty four goats (requiring various clinical procedures) were used and divided randomly into four groups (A, B, C and D) having six animals in each group. In groups A and C, animals were premedicated with a combination of midazolam (@ 0.3 mg/kg body weight i.v.) and butorphanol (@ 0.2 mg/kg body weight i.v.). In groups B and D, animals were premedicated with a combination of dexmedetomidine (@ 5 μg/kg body weight i.v.), midazolam (@ 0.3 mg/kg body weight i.v.) and butorphanol (@ 0.2 mg/kg body weight i.v.) mixed in a single syringe. Induction and maintenance was achieved by propofol in animals of group A (3.35 ± 0.08 mg/kg and 19.92 ± 1.48 mg/kg, respectively), B (2.18 ± 0.01 mg/kg and 8.08 ± 1.37 mg/kg, respectively) and with ketamine in animals of group C (7.17 ± 0.60 mg/kg and 34.19 ± 1.30 mg/kg, respectively), D (2.53 ± 0.12 mg/kg and 13.01 ± 1.01 mg/kg, respectively). The level of anaesthesia was determined on the basis of various clinical, physiological, haematological and biochemical parameters. The preanaesthetic combination of midazolam-butorphanol produced extreme sedation whereas addition of dexmedetomidine with midazolam-butorphanol induced extreme sedation, along with better muscle relaxation and analgesia. The mean induction time was lesser in dexmedetomidine-midazolam-butorphanol premedicated goats as compared to midazolam-butorphanol premedicated goats. Propofol was found better than ketamine as an induction agent in goat because of good induction quality, excellent muscle relaxation, smooth and rapid recovery. It was concluded that dexmedetomidinemidaolam- butorphanol combination has more dose sparing effect than midazolambutorphanol on propofol or ketamine used for induction and maintenance of anaesthesia. None of the drug combinations produced any deleterious effect on vital organ functions and were found safe in goats. Dexmedetomidine-midazolambutorphanol-propofol is a safe anaesthetic combination and could be recommended for surgery requiring one hour duration because of extreme sedation, excellent analgesia, excellent muscle relaxation along with rapid induction and smooth recovery but cost was a major constraint with this combination.
  • ThesisItemOpen Access
    Electroencephalographic and electrocardiographic studies on propofol anaesthesia in sheep
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2011-06) Raj Kumari; Das, Arup Kumar
    In this study electroencephalographic and electrocardiographic changes during surgical interventions {viz., placement of central venous catheters (Group-B), docking/ tail amputation (Group-C), bilateral orchiectomy (Group-D) and no surgical stimuli as control (Group-A)} with propofol anaesthesia were assessed in twenty-four (n=24) apparently healthy male sheep. For surgical operations each sheep of this study was premedicated with glycopyrrolate (@ 0.02 mg/kg body weight, IM) and, five minutes after, anaesthesia was induced with propofol (@ 4.00 mg/kg body weight, IV). The parameters in this study included clinical, cardiopulmonary, haematobiochemical and electrocardiographic parameters. Similarly, qualitative electroencephalographic evaluation was done through spectral analysis to generate total power, SEF-90, MF and PPF over 0-30 frequency band width while relative power of different bandwidths viz., , , and was assessed. Rectal temperature and respiration rate has not shown any significant variability in any of the groups during the entire course of experiment. Haemoglobin concentration reduced and this extent was higher in control group than central venous catheterization, docking and castration groups. PCV reduced in all the groups. TEC depicted reduction in control group; however, this fall was not apparent in other groups. Blood glucose decreased initially followed by an increase in three groups after propofol induction while the castration group exhibited a non-significant increase from very beginning. Total serum protein declined in all the groups. A sudden increase in serum triglyceride (TG) was observed at one minute post-propofol induction in all the groups, which later on declined. Propofol has not been able to induce any significant changes in P-wave, QRS wave and T-wave amplitude as exhibited in control group. However, P-wave amplitude increased significantly in animals performed with central venous catheterization. The T-wave amplitude increased nonsignificantly in CVC group while decrease in docking and castration groups. P-wave and T-wave duration has not exhibited any significant difference throughout the course of experiment. However, QRS wave duration decreased in control group and no significant changes were observed in surgical groups. PR segment length reduced in castration group only and none of the other groups exhibited any significant changes. ST segment length exhibited significant increase in control group, non-significant increase in CVC while exhibiting significant fall in castration and docking groups. RR interval exhibited reduction in all the four groups, non-significantly in control while significantly in the three surgical groups. Heart Rate increased in all the four groups. EEG analysis showed an increase in total power, median frequency, theta frequency, peak power in all group, and after a transient increase reduction in spectral edge frequency and alpha frequency. However delta frequency showed an increase after a transient decrease and a marked decrease in beta frequency after propofol injection. It was concluded that propofol to some extent possess analgesic effect and may be useful in husbandry practices/ day case surgery. However, evaluation of analgesic effects of propofol needs further investigation.