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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Clinico-biochemical, diagnostic and therapeutic studies in canine cardiac arrhythmia
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2005-01) Gupta, Devendra Kumar; Singh, J.L.
    A clinical survey was aimed for identifying the prevalence of cardiac arrhythmia among the canines in some parts of India. Overall 6.6% prevalence of cardiac arrhythmia was recorded in present clinical survey. Area wise, crime branch police dogs Delhi (34.9%) showed highest prevalence while Pantnagar showed lowest prevalence (4.7%). In other areas, prevalence rate was 7.0%, 5.9% and 5.0% in Mathura, Indore and Gwalior, respectively. In age and sex wise prevalence, cardiac arrhythmia was seen mainly in dogs aged two to six years (10.6%). Breed and sex wise, highest prevalence was in Labrador (11%). Overall females are more prone for cardiac arrhythmia as compared to males. Tachyarrhythmia (51.7%) was most commonly observed arrhythmia in canines followed by bradyarrhythmia (39.6%) and arrhythmia with normal heart rate (8.7%) was next in sequence of occurrence. Exercise intolerance, persistent nocturnal coughing, upright posture, dyspnoea and ascites were important clinical signs in cardiac arrhythmia. Among the various diagnostic procedures adopted in present study, auscultation proved to be the most valuable means of diagnosing heart diseases. ECG detected various abnormalities, which could not be detected by physical examination alone. Amplitude of P and R waves increased as per increased heart rate, while no significant alteration was reported in T wave as heart rate changes. P-R and Q-T intervals were inversely proportional to the heart rate. Radiography was found to be as useful as ECG in confirmatory diagnosis of cardiac arrhythmia. Haematological profile except haemoglobin did not show any significant alteration in cardiac arrhythmia. Increased levels of serum sodium and calcium and low levels of potassium and magnesium were found in tachyarrhythmia whereas increased level of sodium, potassium and magnesium were found in bradyarrhythmia. There was significant elevation of blood glucose, total protein, cholesterol and triglycerides in tachyarrhythmia while no significant alteration of these was noticed in bradyarrhythmia. AST, CK and LDH activities were found high in tachyarrhythmia while CK activity suppressed in bradyarrhythmia. Antiarrhythmic medicine atenolol and verapamil was effective in cases of tachyarrhythmia. Verapamil was found very effective in severe tachyarrhythmia (> 190 beats/min) and atenolol in mild types of tachyarrhythmia. In respect to therapeutic management of bradyarrhythmia, terbutaline was found superior in comparison to theophylline + etophylline combination.
  • ThesisItemOpen Access
    Biochemical profiles to forecast post- parturient paresis in cross bred cows
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2005-08) Satya Vikas; Rajora, V.S.
    The present investigation was undertaken to record the prevalence of post parturient paresis, to evaluate biochemical profiles in peri parturient crossbred cows and to study shift in normal pattern of the profiles to identify the metabolic markers to forecast the occurrence of parturient paresis. The prevalence was computed on the basis of records collected from Veterinary Teaching Hospital, Pantnagar and State Veterinary Hospitals around Pantnagar for a period of five years from 2000 to 2004. Of 26802 cases in crossbred cows, 254 (0.95 percent) were found to be having metabolic disorders out of which 152 (59.84 percent) were of post parturient paresis. Highest prevalence of post-parturient paresis was recorded in the winter season. The blood and urine samples were collected at 48 hrs pre calving and 24, 48 and 72 hrs post calving in healthy cows and 48 hrs pre calving and 24, 48 hrs and at the time of the disease in the affected cows. In this study in healthy cows the plasma calcium, plasma inorganic phosphorous, plasma creatinine, plasma calcium and inorganic phosphorous ratio and urinary creatinine did not differ significantly at 48 hrs pre calving and 24, 48 and 72 hrs post calving, whereas the urinary hydroxyproline and the ratio between urinary hydroxyproline and urinary creatinine increased at 24, 48 and 72 hrs post calving in comparison to the 48 hrs pre calving. In cows developing post parturient paresis the plasma calcium decreased significantly at 24 and 48 hrs post calving and at the time of disease in comparison to the levels at 48 hrs pre calving in paretic and healthy cows. Plasma inorganic phosphorous concentrations decreased at the time of disease in comparison to the concentration at 48 hrs pre calving. Plasma Ca:iP ratio at 24 hrs post calving and at the time of disease decreased significantly in comparison to the ratio at 48 hrs pre calving of affected cows and 24 and 48 hrs post calving of healthy cows. Urinary hydroxyproline and ratio between urinary hydroxyproline and urinary creatinine decreased significantly at 24 and 48 hrs post calving and at the time of disease. The findings of the study will be of immense use in monitoring sub clinical parturient hypocalcaemia and as an aid to forecast the occurrence of parturient paresis for evolving the specific control programmes.
  • ThesisItemOpen Access
    Clinico-pathological, diagnostic and therapeutic studies of cystitis in canines
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2005-06) Satyendra Kumar; Singh, J.L.
    The present study was aimed for identifying the prevalence of cystitis among the canines in some parts of India. Based on retrospective study of hospital record, cystitis was more prevalent in Pantnagar during 2004-2005. However, cystitis based on clinical screening was more prevalent in Mathura. Cystitis was seen mainly in female dogs of above six years age. Dysuria, haematuria, frequent painful micturition, pollakiuria, squatting posture and incontinence were the important clinical signs suggestive of cystitis. Routine clinical parameters namely rectal temperature and heart, pulse and respiration rates were increased in cystitis significantly. Haematological study revealed significant increase in TLC and neutrophil counts, while significant decreases were found in haemoglobin levels and lymphocyte numbers. Serum creatinine and urea nitrogen were increased significantly, while serum glucose level was decreased significantly. Serum albumin and albumin/globulin ratio were decreased significantly. However, serum globulin was increased significantly. Serum sodium and calcium level were significantly low in value. Whereas analytical value of serum inorganic phosphorus was high in cystitis. Serum alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) level were increased significantly in cystitis. In present study, urine pH and specific gravity were increased significantly. Protein, urea nitrogen and creatinine in urine were increased significantly in cystitis. The ratio of urinary protein/cretinine was observed significantly high in cystitis affected dogs. Alkaline phosphatase (ALP) and Gamma glutamyl transferase (GGT) level in urine were increased significantly in cystitis. The bacteria commonly identified in this work were E.coli., Staph.Spp., Strept. Spp., Klebsiella spp.,Proteus spp. and Pseudomonas spp. Contrast cystographic study of urinary bladder demonstrated distended irregular shaped sac with a smooth mucosal surface. In USG study, the lumen of urinary bladder in all cases found to be anechoic in appearance surrounded by hyperechoic bladder wall. Echogenic accumulations (thickened bladder wall) in the dependent region of the urinary bladder were found as another prominent sonographic lesions of cystitis. Therapeutic management point of view, Doxycycline was found as antibiotic of primary choice followed by Cefotaxime, Amikacin and Oflaxacin as secondary, tertiary and quarternary choice, respectively.
  • ThesisItemOpen Access
    Biochemical profiles to forecast post-parturient paresis in cross bred cows
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2005-08) Satya Prakash; Rajora, V.S.
    The present investigation was undertaken to record the prevalence of post parturient paresis, to evaluate biochemical profiles in peri parturient crossbred cows and to study shift in normal pattern of the profiles to identify the metabolic markers to forecast the occurrence of parturient paresis. The prevalence was computed on the basis of records collected from Veterinary Teaching Hospital, Pantnagar and State Veterinary Hospitals around Pantnagar for a period of five years from 2000 to 2004. Of 26802 cases in crossbred cows, 254 (0.95 percent) were found to be having metabolic disorders out of which 152 (59.84 percent) were of post parturient paresis. Highest prevalence of post-parturient paresis was recorded in the winter season. The blood and urine samples were collected at 48 hrs pre calving and 24, 48 and 72 hrs post calving in healthy cows and 48 hrs pre calving and 24, 48 hrs and at the time of the disease in the affected cows. In this study in healthy cows the plasma calcium, plasma inorganic phosphorous, plasma creatinine, plasma calcium and inorganic phosphorous ratio and urinary creatinine did not differ significantly at 48 hrs pre calving and 24, 48 and 72 hrs post calving, whereas the urinary hydroxyproline and the ratio between urinary hydroxyproline and urinary creatinine increased at 24, 48 and 72 hrs post calving in comparison to the 48 hrs pre calving. In cows developing post parturient paresis the plasma calcium decreased significantly at 24 and 48 hrs post calving and at the time of disease in comparison to the levels at 48 hrs pre calving in paretic and healthy cows. Plasma inorganic phosphorous concentrations decreased at the time of disease in comparison to the concentration at 48 hrs pre calving. Plasma Ca:iP ratio at 24 hrs post calving and at the time of disease decreased significantly in comparison to the ratio at 48 hrs pre calving of affected cows and 24 and 48 hrs post calving of healthy cows. Urinary hydroxyproline and ratio between urinary hydroxyproline and urinary creatinine decreased significantly at 24 and 48 hrs post calving and at the time of disease. The findings of the study will be of immense use in monitoring sub clinical parturient hypocalcaemia and as an aid to forecast the occurrence of parturient paresis for evolving the specific control programmes.
  • ThesisItemOpen Access
    Therapeutic evaluation of some ethnomedicinal plants against Fasciola gigantica
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2005-06) Parihar, Ganesh Singh; Upadhyay, A.K.
    Various organic solvent and aqueous extracts of three ethnomedicinal plants viz., Butea frondosa, Embelia ribes and Mallotus philippensis were evaluated for their in vitro efficacy against Fasciola gigantica. The extracts were phytochemically analysed for presence of various groups of chemical compounds. Effective extracts were fractionated and characterized through HPTLC. Two (2.5 and 5.0 mg/ml) concentrations of all the extracts were prepared in H-F solution. Similar concentrations of three standard antitrematodal drugs viz., Triclabendazole, Rafoxanide and Closantal were also prepared to run positive control test. The results obtained form each of the extract were compared with that of standards and cumulative efficacies of the extracts and overall efficacies of the plant materials were analysed and interpreted. Mallotus philippensis showed maximum overall efficacy (49.05 % and 46.67 % at 2.5 and 5.0 mg/ml concentrations respectively). Butea frondosa showed 41.43 and 40.95 % whereas Embelia ribes gave 31.43 and 30.95 % overall efficacies at 2.5 and 5.0 mg/ml concentrations respectively. Butea frondosa showed maximum cumulative efficacy in its benzene extract (80.00 and 73.33 % at 2.5 and 5.0 mg/ml concentrations respectively) whereas Mallotus philippensis gave maximum cumulative efficacy with cold aqueous extract (73.33 % in both the concentrations). Embelia ribes showed maximum 46.67 % cumulative efficacy in methanol extract at 2.5 mg/ml and 50.00 % cumulative efficacy in hexane extract at 5.0 mg/ml. Phytochemical analysis was carried out to detect alkaloids, anthraquinones, coumarins, flavonoids, glycosides, proteins, reducing sugars, resins, saponins, sterols, tannins and triterpenes. All the chemical groups were present in one or another extract of Butea frondosa except flavonoids. Flavonoids, proteins and sterols were absent in extracts of Embelia ribes whereas anthraquinones, flavonoids, proteins and reducing sugars could not be detected in any extract of Mallotus philippensis. Determination of Rf values and absorption maxima of the substances present in the effective extracts was carried through HPTLC.
  • ThesisItemOpen Access
    Studies on natural outbreaks of Marek’s disease in vaccinated domestic fowl with special reference to PCR based diagnosis
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2005-07) Agrawal, Vishal Shyamsundar; Shukla, S.K.
    The present investigation was undertaken to study the prevalence, clinico biochemical changes, histopathological changes, frequency of organ involvement, pathogenicity testing and PCR based diagnosis of Marek’s disease (MD). The samples and data were collected by personal visits to the poultry farms located in U. S. Nagar district of Uttaranchal. Incidence of MD ranged between 0.59 – 26.31% with an average of 9.17% in all the 7 farms. Mortality in birds gradually decreased as the age advanced. Maximum mortality was found during first part of laying phase. Clinical signs includes typical posture of one leg stretched forward and one backward, leg paralysis, incoordination, off feed, gradual reduction in body weight, prominent keel bone, curling of toes, torticollis and thickening and paleness of comb. Post mortem lesions included thickening of sciatic nerve with loss of striation and tumourous lesions or diffuse enlargement of visceral organs. Microscopically, most of the organs revealed loss of normal architecture, which was evident by degeneration and necrosis and massive pleomorphic cell infiltration. Reduction in Hb, PCV, heterophils, MCV and MCH and increase in TLC, ESR, lymphocytes were noticed. However no alteration in TEC, monocytes, eosinophils and basophils and MCHC values was recorded. Elevated plasma total protein, globulin, cholesterol, LDH, creatinine kinase, creatinine, BUN AST, ALT, AKP levels and decrease in A:G ratio were observed. No alteration in albumin and creatinine kinase MB levels was noticed. Plasma sodium, potassium and magnesium values were significantly higher with low calcium level in the infected birds. However, no alteration in plasma phosphorus level in infected birds was noticed. Investigation revealed 64% of the feather follicle samples positive for MD precipitinogen by standard antiserum. PCR by using specific primers for gA gene of MDV 1 amplify antigen A gene fragment of pathogenic MDV from feather, blood, liver, spleen. The amplified DNA product of 314 bp was detected on agarose (1.7%). HVT specific primers amplified none of the DNA isolated from infected samples. The probable reasons for the vaccination failures are early infection of chicks with virulent strain, maternal antibodies interfering with vaccinal immunity, mutation of MDV to vMDV, rearing of birds of multiple ages on same premises, mismanagemental practices, excessive dilution of vaccine, immunosuppression and lack of biosecurity measures.
  • ThesisItemOpen Access
    Therapeutic evaluation of garlic (Allium sativum) in bovine mastitis
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2008-05) Mohd. Reyaz; Rajora, V.S.
    The present course of investigation was carried out with the objectives to standardize minimum inhibitory concentration (MIC) of garlic extract against bacterial mastitogens and to evaluate intramammary infusion of aqueous garlic extract in the treatment of mastitis in cows. The over all prevalence of mastitis in crossbred cows of varying parity and stages of lactation maintained at Instructional dairy farm, GBPUA&T, Pantnagar (Uttarakhand) was recorded to be 11.86% with more frequent involvement of hind quarters. The occurrence of mastitis was observed to be more upto 60 days post calving and in cows of fourth lactation. The flakes were observed in 75%, pus in 20.83% and watery milk in 4.17% cases. The MIC of crude garlic extract was found to be between 12.5 to 25 mg/ml and garlic in a concentration of upto 100 mg/ml gave clear zone of inhibition against bacterial mastitogens. Twenty four cows showing clinical mastitis were randomly divided equally into three groups for therapeutic evaluation of intramammary infusions of crude garlic extract at 200 mg/ml and 100 mg/ml concentrations and Pendistrin-SH in groups I, II and III, respectively. Besides mild to severe swelling, local pain, warm to hot and firm to hard consistency of udder, presence of the flakes (75%), pus (20.83%) or watery milk (4.13%) was observed in cases of clinical mastitis included in the present study. Affected quarters had significantly higher somatic cell counts (SCC), pH and chloride levels and lower values of milk compositional profile viz. fat, total solids and solids-not-fat in comparison to normal healthy quarters. Biochemical characterization indicated Staphylococcus spp., Streptococcus spp. and Escherichia coli in 11 (45.83%), 5 (20.84%) and 8 (33.33%) milk samples from mastitic quarters. Intramammary infusion of crude garlic extract at the concentration of 200 mg/ml showed 12.5% therapeutic efficacy with resolution in 25% and improvement in 75% cases in terms of swelling, pain, warmness and consistency of the udder. The recoveries in the groups treated with intramammary infusion of garlic extract at 100 mg/ml concentration and Pendistrin-SH were observed to be 50% and 75% respectively with significant improvements in chloride contents, pH and SCC and resolution of clinical manifestations. Crude garlic extract cured 100% and 50% cases infected with Escherichia coli at the concentrations of 100 mg/ml and 200 mg/ml respectively, but slight irritation was observed with crude garlic extract at the concentrations of 200 mg/ml. The Pendistrin-SH was found to cure all the cases except infected with Escherichia coli. Post therapy disappearance of flakes was recorded in all the recovered cases. Crude garlic extract at 100 mg/ml concentration was found to be an effective alternative for the treatment of clinical mastitis infected with Escherichia coli.