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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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Author: DEVADA, SHILPESHKUMAR SAMPATLAL × Start date: 2010 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON EFFECT OF PIPERINE ON PHARMACOKINETICS OF GATIFLOXACIN AND SAFETY OF GATIFLOXACIN IN BROILER BIRDS
    (AAU, Anand, 2010) DEVADA, SHILPESHKUMAR SAMPATLAL; THAKER, A. M.
    Gatifloxacin is a newer, fourth-generation, 8-methoxy fluoroquinolone that exhibits broad spectrum of antibacterial activity than the older fluoroquinolones. The present study was designed to investigate pharmacokinetics of gatifloxacin following single dose intravenous and oral administration at the dose rate of 10 mg/kg of body weight, to determine effect of piperine coadministration at the rate of 15 mg/kg of body weight on the pharmacokinetics of the gatifloxacin at the rate of lOmg/kg of body weight and to evaluate safety and tissue distribution after repeated oral administration (10 mg/kg) of gatifloxacin at 12 hours interval for 14 days in broiler birds. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). Pharmacokinetic parameters were calculated using noncompartmental approach. Following intravenous administration the therapeutically effective serum concentration of gatifloxacin > 0.36 fxg/ml was maintained for up to 12 hours. Based on the plasma gatifloxacin concentrations, various pharmacokinetic parameters like elimination half-life (t1/2β) (3.62 ± 0.03 hours), apparent volume of distribution (Vd(area)) (2.5 ± 0.025 1/kg), volume of distribution of drug at steady-state (Vd(ss)) (2.19 ± 0.015 1/kg), total body clearance (CIB) (0.48 ± 0.002 l/hr/kg), area under plasma drug concentration-time curve (AUC) (20.89 ± 0.101 µg-h/ml), area under first moment of curve (AUMC) (95.63 ± 0.78 µg-h2/ml) and mean residence time (MRT) (4.58 ± 0.027 hours) were determined.