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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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20103
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Subject: Veterinary Pharmacology and Toxicology × End date: 2010 × Start date: 2010 × Type: Thesis ×
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    ThesisItemOpen Access
    STUDIES ON EFFECT OF PIPERINE ON PHARMACOKINETICS OF GATIFLOXACIN AND SAFETY OF GATIFLOXACIN IN BROILER BIRDS
    (AAU, Anand, 2010) DEVADA, SHILPESHKUMAR SAMPATLAL; THAKER, A. M.
    Gatifloxacin is a newer, fourth-generation, 8-methoxy fluoroquinolone that exhibits broad spectrum of antibacterial activity than the older fluoroquinolones. The present study was designed to investigate pharmacokinetics of gatifloxacin following single dose intravenous and oral administration at the dose rate of 10 mg/kg of body weight, to determine effect of piperine coadministration at the rate of 15 mg/kg of body weight on the pharmacokinetics of the gatifloxacin at the rate of lOmg/kg of body weight and to evaluate safety and tissue distribution after repeated oral administration (10 mg/kg) of gatifloxacin at 12 hours interval for 14 days in broiler birds. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). Pharmacokinetic parameters were calculated using noncompartmental approach. Following intravenous administration the therapeutically effective serum concentration of gatifloxacin > 0.36 fxg/ml was maintained for up to 12 hours. Based on the plasma gatifloxacin concentrations, various pharmacokinetic parameters like elimination half-life (t1/2β) (3.62 ± 0.03 hours), apparent volume of distribution (Vd(area)) (2.5 ± 0.025 1/kg), volume of distribution of drug at steady-state (Vd(ss)) (2.19 ± 0.015 1/kg), total body clearance (CIB) (0.48 ± 0.002 l/hr/kg), area under plasma drug concentration-time curve (AUC) (20.89 ± 0.101 µg-h/ml), area under first moment of curve (AUMC) (95.63 ± 0.78 µg-h2/ml) and mean residence time (MRT) (4.58 ± 0.027 hours) were determined.
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    ThesisItemOpen Access
    STUDIES ON EFFECT OF FEVER AND COADMINISTRATION OF KETOPROFEN ON PHARMACOKINETICS OF CEFEPIME AND SAFETY OF REPEATED SIMULTANEOUS INTRAMUSCULAR ADMINISTRATION OF CEFEPIME AND KETOPROFEN IN SHEEP
    (AAU, Anand, 2010) PATEL, NIMESHKUMAR NATVARLAL; Bhavsar, S. K.
    Cefepime is a novel fourth generation, semi-synthetic cephalosporin with broad spectrum antibacterial activity and also effective against the bacteria that are resistant to conventional antibacterial drugs. Use of non-steroidal anti-inflammatory drugs (NSAIDs) are frequently recommended with antibacterials for the treatment of various bacterial infections accompanied by fever and other inflammatory conditions in animals. Ketoprofen is an aryl propionic acid derivative, non-selective cyclooxygenase (COX) inhibitor NSAID having anti-inflammatory, analgesic and antipyretic properties. Pharmacokinetics of an antibacterial drug may change when administered with anti-inflammatory drug or in febrile condition in animals. The present study was planned to deterrnine the effect of intramuscularly administered ketoprofen (3 mg kg-1) and febrile condition [ E. coli lipopolysaccharide (LPS) induced] on pharmacokinetics of cefepime following intramuscular administration (20 mg k-1) in sheep and safety of daily intramuscular administration of cefepime (20 mg kg-1 at 12 h interval) in combination with intramuscular administration of ketoprofen (3 mg kg-1 at 24 h interval) for five days in sheep by monitoring haematological and blood biochemical profiles.
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    ThesisItemOpen Access
    STUDIES ON EFFECT OF FEVER AND CO-ADMINISTRATION OF KETOPROFEN ON PHARMACOKINETICS OF CEFEPIME AND SAFETY OF REPEATED SIMULTANEOUS INTRAMUSCULAR ADMINISTRATION OF CEFEPIME AND KETOPROFEN IN GOATS
    (AAU, Anand, 2010) PATEL, HIREN BABULAL; Bhavsar, S. K.
    Antibacterial are frequently recommended as an adjunct therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) to treat various bacterial infections accompanied by fever and other inflammatory conditions in animals. Cefepime, a fourth-generation semi-synthetic broad spectrum cephalosporin has bactericidal action against broad range of bacteria including those that are resistant to conventional antibacterial drugs. Ketoprofen is an aryl propionic acid derivative, non-selective cyclooxygenase (COX) inhibitor NSAID having anti-inflammatory, analgesic and antipyretic properties. Pharmacokinetics of an antibacterial drug may change when administered with anti-inflammatory drug or in febrile animals. Despite the great potential for clinical use of cefepime, the data on its pharmacokinetics and safety profile in goats are scarce. The present study was planned to determine the effect of fever (E. coli lipopolysaccharide-induced) and co-administration of ketoprofen (3 mg kg-1) on pharmacokinetics of cefepime following intramuscular (20 mg kg-1) in goats and safety of daily intramuscular administration of cefepime administration (20 mg kg-1) in combination with intramuscular administration of ketoprofen (3 mg kg-1) for five days in goats by monitoring haematological and serum biochemical profiles.