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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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20141
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Subject: Veterinary Pharmacology × Start date: 1965 × Thesis Type: M.Sc ×
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    ThesisItemOpen Access
    STUDIES ON EFFECT OF TOLFENAMIC ACID AND BIOENHANCER TRIKATU ON PHARMACOKINETICS OF CEFQUINOME AND SAFETY OF SIMULTANEOUS ADMINISTRATION OF CEFQUINOME AND TOLFENAMIC ACID IN PATANWADI SHEEP
    (AAU, Anand, 2014) RANA, MAYANKKUMAR PRABHUBHAI; Dr. A. M. Thaker
    Antibacterials are frequently recommended as an adjunct therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) to treat various bacterial infections and inflammatory conditions in animals. Cefquinome is a fourth-generation cephalosporin, which has been developed solely for veterinary use. It shows potent antibacterial activity against a broad spectrum of bacterial species including those that are resistant to conventional antibacterial drug. Tolfenamic acid (TA) is a new NSAID having antiinflammatory, analgesic and antipyretic properties. In veterinary practice, tolfenamic acid is used clinically as an anti-inflammatory and analgesic agent for the therapy of locomotor diseases in the dog and post-operative pain in cats. Pharmacokinetics of an antibacterial drug may change when administered with anti-inflammatory drug. Despite the potential for clinical use of cefquinome, the data on its pharmacokinetics interaction and safety profile in sheep are not available. Ancient and recent scientific literature cited reference of bioenhancer like trikatu application to increase bioavailability of drug and nutrients. Moreover, it is well known in ruminant animals that oral bioavailability of drug is low as compared to monogastric animals. Looking to this, present study was conceptualized to determine the effect of tolfenamic acid (2 mg/kg body weight) on pharmacokinetics of cefquinome (2 mg/kg body weight) following its intramuscular administration in sheep and safety of daily intramuscular administration of cefquinome (2 mg/kg body weight) in combination with tolfenamic acid (2 mg/kg body weight) for five days in sheep by monitoring hematological and blood biochemical profiles. Moreover, effect of bioenhancer trikatu on pharmacokinetics of cefquinome following intramuscular administration (2 mg/kg body weight) in sheep was evaluated.