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Subject: Veterinary Pharmacology ×

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Now showing 1 - 6 of 6
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    ThesisItemOpen Access
    Revanasiddappa
    (KVAFSU, Bidar, 2019) Revanasiddappa
    The study was taken up to evaluate the pharmacological and toxicological property of Phyllanthus reticulatus plant. Phytochemical analysis revealed the presence of carbohydrates, starch, flavonoids, phenolic compounds, tannins, saponins, phytosterols and triterpenoids. The study was conducted to evaluate the in vivo anti-inflammatory and analgesic property of the plant extract using carrageenan induced paw oedema and acetic acid induced writhings as peripheral pain model respectively and selected dose levels of pant extract are 50, 100 and 200 mg/kg. This revealed significant (p < 0.05 or p < 0.01) anti-inflammatory and analgesic activity at 100 and 200 mg/kg. Acute oral and repeated dose 28 day oral toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 423 and 407 respectively. In acute toxicity a dose levels of 300, 2000 and 5000 mg/kg were studied. In repeated dose 28 day oral toxicity study dose levels of 500, 750 and 1000 mg/kg were administered daily for 28 days and compared with the control rats. In toxicity studies, no mortality and toxicity signs were observed. The MTD value was found to be more than 5000 mg/kg. Haematological and biochemical parameters were within the reference range, although AST was shown significant increase (p < 0.01) in the repeated dose oral toxicity study of the extract. The histopathological changes observed were restricted to vascular changes, inflammatory cells infiltration and degenerative changes in extract treated groups and were very mild to mild signs. The plant leaves showed significant anti-inflammatory and analgesic property that can be utilized to explore the therapeutic efficacy. Key words: Phyllanthus reticulatus, Phytochemical analysis, Anti-inflammatory activity, Toxicity study, Wistar albino rats.
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    ThesisItemOpen Access
    LACTATION INDUCTION IN UNPRODUCTIVE CATTLE
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2021-03) ARUNKUMAR KORI; JAGADEESH S SANGANAL
    The study was conducted to induce lactation with the help of hormones or drugs in unproductive dairy cattle. Two groups of cattle (Groups I and II, n=10) were treated with 0.1 mg/kg estradiol – 17 β and 0.25 mg/kg progesterone S/C for seven consecutive days. Group I animals were administered with dexamethasone (20 mg/day) and reserpine (5 mg TD/day) and Group II animals were administered with dexamethasone (20 mg/day) and metoclopramide (0.1mg/kg) IM, on days 14 to 17. Both the groups of animals were synchronized by double PGF2α protocol in 10 days apart prior to initiation of hormone therapy. Results revealed that the 90 day mean milk production in Group I and Group II were 326.44 ± 21.30 litres and 387.82 ± 19.40 litres, respectively. It was suggested that administration of progesterone and estradiol – 17 β with PGF2α, dexamethasone, reserpine or metoclopramide was a viable method of inducing lactation in unproductive dairy cattle. Synchronizing estrous cycles of cows prior to initiation of lactation-induction protocol with two injections of PGF2α 10 days apart, improved success rates of induced lactations. Cost-benefit analysis was more for metoclopramide than reserpine treatment group. Lactation in induced cows could be maintained with good nutrition and managemental practices.
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    ThesisItemOpen Access
    EVALUATION OF INVITRO ANTIMICROBIAL ACTIVITY OF Simarouba glauca ELECTROSPUN NANOFIBERS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2019-08) KANIKA SUDHAKAREN; KANIKA SUDHAKAREN; dr. JAGADEESH S. SANGANAL; dr. JAGADEESH S. SANGANAL
    The present study was conducted to synthesis nanofibers from methanolic leaves extract of Simarouba glauca by an efficient protocol of electrospinning technique using a mixture of Polyvinyl pyrrolidine and S. glauca extract in various concentrations viz, 8%, 12% and 14%.The phytochemical analysis of the plant extract were done and showed the presence of various secondary metabolites such as carbohydrates, proteins, alkaloids, flavonoids, tannins, phenolics, glycosides, anthraquinones, phytosterols and triterpenoids. The physico-chemical properties and the interaction between the plant extract and the polymer were analysed using SEM and FTIR. The invitro antibacterial activity of the plant extract nanofibers were studied by using Kirby- Bauer disc diffusion assay. Results obtained from the study indicates that the synthesised plant extract nanofibers possess antibacterial property against food spoilage microorganisms. Also found that when the plant extract concentration in the nanofibers increased, the antibacterial property was increased. Hence, it was concluded that extract can be used as source of natural antimicrobial compou
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    ThesisItemOpen Access
    EVALUATION OF INVITRO ANTIMICROBIAL ACTIVITY OF Simarouba glauca ELECTROSPUN NANOFIBERS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2019-08) KANIKA SUDHAKAREN; Dr. JAGADEESH S. SANGANAL
    The present study was conducted to synthesis nanofibers from methanolic leaves extract of Simarouba glauca by an efficient protocol of electrospinning technique using a mixture of Polyvinyl pyrrolidine and S. glauca extract in various concentrations viz, 8%, 12% and 14%.The phytochemical analysis of the plant extract were done and showed the presence of various secondary metabolites such as carbohydrates, proteins, alkaloids, flavonoids, tannins, p
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    ThesisItemOpen Access
    PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF VITEX NEGUNDO IN RATS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2017-08) PURANDAR B KAMBLE; Dr. N. B. SHRIDHAR
    The present study was conducted to evaluate various pharmacological and toxicological properties of the Vitex negundo extract. Phytochemical analysis revealed the presence of carbohydrates, glycosides, flavonoids, phenolics, tannins, Phytosterols, triterpenoids. Acute oral and sub-acute toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 401 and 407 respectively. In acute toxicity study, the LD50 cut off value was found to be more than 5 g/kg. No mortality and toxicity signs were observed. In sub acute toxicity study, methanol extract was administered @ 500, 1000, 2000 and 5000 mg/kg respectively and compared with the control rats. The results of body weight, gross and histopathological observations of the treated groups indicated the non toxic nature of the extract even @ 5000 mg/kg. In in vivo anti-inflammatory study of methanol extract, in carrageenan induced rat paw edema model, the extract @ 500 and 1000 mg/kg showed significant inhibition of rat paw edema in dose dependent manner indicating its anti inflammatory activity
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    ThesisItemOpen Access
    TOXICITY STUDIES OF FUNGAL ISOLATES IN RATS AND MICE FROM PADDY STRAW SUSPECTED TO CAUSE NECROSIS OF EXTREMITIES IN BUFFALOES
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2008-07) SHIVAPRASAD, G. R.; N. B.«SHRIDHAR; K. JAYAKUMAR; H. D. NARAYANASWAMY; (S. G. RAMACHANDRA; S. YATHIRAJ
    In most developing countries, livestock production is an important part of national economy. A major constraint for increased milk production by small and medium dairy farmers is the chronic shortage of affordable feeds of adequate quality and quantity, particularly during the dry season. The problem of feed storage is further complicated by farmer’s inability to use them before they spoil, especially during wet season when there is a production peak. During peak production, one of the major agents of feed spoilage, are moulds. Though their prevalence and rate of colonization are highly dependent on climate and farm practices, the growth of moulds in raw material and finished feeds of livestock is an universal problem. Mould spores, of the so called field fungi, can contaminate cereal grains and stover in standing crop in severe conditions (too wet or too dry season). These include species of Fusarium, Altemaria, Cladosporium, Diplodia, Gibberella and Helminthosporium, their spores can germinate, especially under high moisture conditions (20-21%). The moulds can also c olonize on feed ingredients and feeds during storage especially with Aspergillus and Penicillium species at 13-18% moisture. Both field and storage fungi can result in elaboration of mycotoxins.