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Subject: Veterinary Surgery and Radiology × Author: BINDUSHREE PANDITH P. N. × End date: 2023 × Start date: 2020 × Type: Thesis ×
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    ThesisItemOpen Access
    EVALUATION OF BUTORPHANOL PREMEDICATED TILETAMINE ZOLAZEPAM AND DEXMEDETOMIDINE KETAMINE BOLUS INDUCTION UNDER ISOFLURANE ANAESTHESIA FOR SURGERY IN CATS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR – 585 226, 2022) BINDUSHREE PANDITH P. N.; DODDAMANI JAHANGIRBASHA
    The study was carried out in 24 clinical cases of cats which were randomly divided into two groups consisting of 12 cats in each group to evaluate the feasibility of butorphanol- tiletamine-zolazepam-isoflurane (group I) and butorphanoldexmedetomidine- ketamine- isoflurane (group II) anaesthesia for various surgeries. The cats in both the groups were pre- medicated with butorphanol (0.2 mg/kg I/M). Five minutes after butorphanol administration, group I cats were induced with tiletamine-zolazepam (10 mg/kg, IV) and group II cats with dexmedetomidine (15 μg/kg, IV) + ketamine (15 mg/kg, IV) as single bolus, followed by maintenance with isoflurane (1-2%) in both the groups. Induction was quicker and smooth in group I cats. Whereas, prolonged and smooth in group II. Apneustic breathing was noticed in group I and in group II transient apnea was observed. The signs were more pronounced in Persian breed of cats in both the groups. Recovery time after disconnecting general anaesthesia was earlier in group II cats. Time to regain sternal position and for complete anaesthetic recovery were significantly longer in group I cats. Degree of muscle relaxation and prolonged analgesia was comparatively better in cats of group II when compared to group I. Cardio-respiratory values were observed to be more stable in group I cats. The decrease in rectal temperature was more severe in group I cats. Haemato-biochemical parameters viz., haemoglobin, packed cell volume and total erythrocyte count decreased throughout the study in both the groups of cats. Total leucocyte count increased non- significantly in group II cats whereas decreased in group I cats. Serum alanine transaminase level increased at 60 minutes after general anaesthesia in both the groups. However, group II cats had higher level of serum alanine transaminase. No significant difference was observed in serum creatinine and serum urea nitrogen at all intervals of study in both the groups. Serum glucose increased significantly at 30 and 60 minutes after general anaesthesia in both the groups. However, all the haemato-biochemical changes were within physiological limits. Apneustic breathing pattern during induction, enhanced muscular rigidity of limbs and tail, hyper-responsive to external stimuli and ataxia before standing and when walking during recovery was noticed in all the cats in group I. In cats of group II apnea was more severe in three Persian cats during induction requiring resuscitation and revival under oxygen supplementation. In present study, both the anaesthetic protocols provided satisfactory surgical plane of anaesthesia. Cardiorespiratory values were observed to be more stable in butorphanol-tiletamine-zolazepamisoflurane administered cats. However, butorphanol-dexmedetomidine-ketamineisoflurane anaesthesia was more ideal to perform surgeries in cats with early recovery.