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Theses (PG)

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20176
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Subject: Veterinary Pharmacology and Toxicology × End date: 2017 × Start date: 2017 × Type: Thesis ×
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Now showing 1 - 6 of 6
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    ThesisItemOpen Access
    STUDIES ON NEUROBIOCHEMICAL AND NEUROPHARMACOLOGICAL ACTIVITIES IN WISTAR RATS EXPOSED TO ARSENIC WITH OR WITHOUT EXOGENOUS MELATONIN ADMINISTRATION
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2017-08) PRASADA NINGAPPA DURAPPANAVAR; PRAKASH NADOOR)
    (‘As’) induced alterations in neurobiochemestry in brain and its impact on neuropharmacological activities with or without the melatonin (MLT) as an antioxidant given exogenously. Male Wistar rats were randomly divided in to four groups of six each. Group-I served as untreated control, while group-II received ‘As’ [sodium (meta) arsenite; NaAsO2] @ 10 mg.kg-1 b.wt. (p.o) for a period of 56 days. Experimental rats in group-III received treatment similar to group-II but in addition received MLT @ 10 mg.kg-1 b.wt. (p.o) from day 32 onwards. Rats in group-IV received MLT alone from day 32 onwards similar to group-III. Sub-chronic exposure to ‘As’ (group-II) significantly (p0.05) reduction in pain latency. Sub-chronic administration of ‘As’ induced (group-II) significant (p<0.05) increase in the levels of thiobarbituric acid reactive substance (TBARS) called malondialdehyde (MDA) in the brain tissue (5.55±0.57 nmol.g-1), and their levels were significantly (p<0.05) reduced by MLT supplementation (group-III: 3.96±0.15 nmol.g-1). The increase in 3-nitrotyrosine (3-NT) levels in ‘As’ exposed rats indicated nitrosative stress due to the formation of peroxynitrite (ONOO-). However, exogenously given MLT significantly (p<0.05) reduced the 3-NT formation as well as prostaglandin (PGE2) levels in the brain. Similarly MLT administration have suppressed the release of pro-inflammatory cytokines (viz., IL-1β, IL-6 & TNF-α) and amyloid-β1-40 (Aβ) deposition in the brain tissues of experimental rats. To conclude, exogenous administration of melatonin can overcome the sub-chronic arsenic induced oxidative and nitrosative stress in the CNS, suppressed pro-inflammatory cytokines and restored certain disturbed neuropharmacological activities in Wistar rats. Key words: Arsenic (As), Neuropharmacology, Melatonin, Oxidative stress, Wistar rats
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    ThesisItemOpen Access
    PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF VITEX NEGUNDO IN RATS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2017-08) PURANDAR B KAMBLE; Dr. N. B. SHRIDHAR
    The present study was conducted to evaluate various pharmacological and toxicological properties of the Vitex negundo extract. Phytochemical analysis revealed the presence of carbohydrates, glycosides, flavonoids, phenolics, tannins, Phytosterols, triterpenoids. Acute oral and sub-acute toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 401 and 407 respectively. In acute toxicity study, the LD50 cut off value was found to be more than 5 g/kg. No mortality and toxicity signs were observed. In sub acute toxicity study, methanol extract was administered @ 500, 1000, 2000 and 5000 mg/kg respectively and compared with the control rats. The results of body weight, gross and histopathological observations of the treated groups indicated the non toxic nature of the extract even @ 5000 mg/kg. In in vivo anti-inflammatory study of methanol extract, in carrageenan induced rat paw edema model, the extract @ 500 and 1000 mg/kg showed significant inhibition of rat paw edema in dose dependent manner indicating its anti inflammatory activity.
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    ThesisItemOpen Access
    EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF METHANOLIC LEAF EXTRACT OF VOLKAMERIA INERMIS ON PARACETAMOL INDUCED HEPATOTOXICITY IN RATS
    (Karnataka Veterinary Animal And Fisheries Sciences University, Bidar, 2017) YOGESHGOWDA, S
    Plants have been an integral part of human society, since beginning of the civilization
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    ThesisItemOpen Access
    STUDIES ON PHARMACOKINETICS AND BIODISTRIBUTION OF AZITHROMYCIN IN BROILER CHICKENS
    (Karnataka Veterinary Animal And Fisheries Sciences University, Bidar, 2017) SHRUTHI, V.R
    Antimicrobial agents are continuously used in both animals and humans to treat and prevent bacterial infections
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    ThesisItemOpen Access
    STUDIES ON NEUROBIOCHEMICAL ANDNEUROPHARMACOLOGICAL ACTIVITIES IN WISTAR RATS EXPOSED TO ARSENIC WITH OR WITHOUT EXOGENOUS MELATONIN ADMINISTRATION
    (Karnataka Veterinary Animal And Fisheries Sciences University, Bidar, 2017) PRASADA NINGAPPA DURAPPANAVAR
    Environmental contamination of arsenic (â Asâ ), especially in drinking water is a global issue
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    ThesisItemOpen Access
    PHARMACOLOGICAL AND TOXICOLOGICAL STUDY OF CISSUS QUADRANGULARIS IN RATS
    (Karnataka Veterinary Animal And Fisheries Sciences University, Bidar, 2017) ANUSHA KURDEKAR
    Plants have been used for medicinal purposes long before the pre-historic period. Herbal medicines are prepared from the therapeutic experience of practicing for more than hundreds of years