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Subject: Veterinary Pharmacology and Toxicology × Author: BASAVARAJA, G.D. × Start date: 2020 ×
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    ThesisItemOpen Access
    STUDIES ON PHARMACOLOGICAL AND TOXICOLOGICAL ASPECTS OF TRIANTHEMA PORTULACASTRUM IN RATS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2022) BASAVARAJA, G.D.; SHRIDHAR, N.B.
    The study was taken up to evaluate the pharmacological and toxicological property of methanolic extract of aerial parts of the plant T. portulacastrum (METP). Phytochemical analysis revealed the presence of carbohydrates, proteins, alkaloids, saponins, flavonoids, phenolic compounds, tannins, phytosterols and triterpenoids. The study was conducted to evaluate the in vivo anti-inflammatory property of methanolic extract of aerial parts of plant T. portulacastrum using carrageenan induced paw oedema model and the extract at the doses of 400 and 600 mg/kg shown to have significant anti-inflammatory activity. In vivo analgesic activity was conducted by using acetic acid induced writhing as peripheral pain model and the extract at the doses 400 and 600 mg/kg showed significant analgesic activity. Acute oral and repeated dose 28-day oral toxicity studies of METP was carried out in Wistar albino rats as per the OECD guidelines 423 and 407 respectively. In sub-acute oral toxicity dose levels of 500, 1000 and 1500 mg/kg were administered daily for 28 days and compared with the control rats. In both toxicity studies, no mortality and toxicity signs were observed. The MTD value was found to be more than 5000 mg/kg. Haematological and biochemical parameters showed no significant changes and these findings correlate with the observed histopathological features in extract treatment groups. The methanolic extract of aerial parts of the plant showed significant antiinflammatory and analgesic property that can be utilized to explore the therapeutic efficacy. Key words: T. portulacastrum, Phytochemical analysis, Anti-inflammatory activity, Analgesic activity, Toxicity study, Wistar albino rats.