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Subject: Veterinary Pharmacology and Toxicology Ɨ Author: ARURU KEERTHANA Ɨ End date: 2022 Ɨ Start date: 2022 Ɨ Thesis Type: M.V.Sc. Ɨ
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    ThesisItemOpen Access
    STUDIES ON PHARMACOKINETICS AND SAFETY EVALUATION OF MELOXICAM WITH OR WITHOUT CO-ADMINISTRATION OF ANDROGRAPHOLIDE OR BROMELAIN IN RATS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2022) ARURU KEERTHANA; SUNIL CHANDRA, U.
    The present study was designed to evaluate the pharmacokinetic (PK) and safety evaluation of meloxicam (MLX) with or without co-administration of andrographolide (AGL) or bromelain (BRM) in Wistar rats. The pharmacokinetic parameters of MLX in Group I (MLX @ 5 mg.kg-1, p.o.), II (MLX + AGL @ 60 mg.kg-1, p.o) and III (MLX + BRM @ 50 mg.kg-1, p.o) revealed no significant change in observed Tmax of 4 h in all groups (n=8 per group). The PK parameters were analyzed with High Performance Liquid Chromatography (HPLC) and calculated by using PK SolverĀ®, version 2.0. The time vs concentration of MLX data was found best fit in to noncompartmental model. The Cmax of MLX was decreased in Groups II, III compared to Group I. The AUC of MLX was decreased in Groups II and III compared to Group I. The half life of MLX was decreased in Group II, while it had increased in Group III compared with Group I. For the safety evaluation study, the rats were divided into six groups viz: I (control), II (MLX @ 10 mg.kg-1, p.o.), III (AGL @ 60 mg.kg-1, p.o.), IV (BRM @ 50 mg.kg-1, p.o.), V(MLX+AGL) and VI (MLX+BRM). The haematological parameters viz: In Group II, haemoglobin, total erythrocyte count and packed cell volume values were significantly decreased (p<0.05). Liver and kidney function enzymes were increased significantly (p<0.05) in Groups II and VI which was correlated by the histopathology. The study concluded that AGL coadministration had no influence on pharmacokinetics of MLX, while BRM enhanced the half-life of MLX, and there by enhanced the hepatic and renal damage potential of MLX on co-administration indicating the herb drug interactions. Key words: Meloxicam, Andrographolide, Bromelain, Pharmacokinetics, Safety, Interactions