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Theses (PG)

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2017 - 20194
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Subject: Veterinary Pharmacology × End date: 2019 × Start date: 2017 ×
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Now showing 1 - 4 of 4
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    ThesisItemOpen Access
    Revanasiddappa
    (KVAFSU, Bidar, 2019) Revanasiddappa
    The study was taken up to evaluate the pharmacological and toxicological property of Phyllanthus reticulatus plant. Phytochemical analysis revealed the presence of carbohydrates, starch, flavonoids, phenolic compounds, tannins, saponins, phytosterols and triterpenoids. The study was conducted to evaluate the in vivo anti-inflammatory and analgesic property of the plant extract using carrageenan induced paw oedema and acetic acid induced writhings as peripheral pain model respectively and selected dose levels of pant extract are 50, 100 and 200 mg/kg. This revealed significant (p < 0.05 or p < 0.01) anti-inflammatory and analgesic activity at 100 and 200 mg/kg. Acute oral and repeated dose 28 day oral toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 423 and 407 respectively. In acute toxicity a dose levels of 300, 2000 and 5000 mg/kg were studied. In repeated dose 28 day oral toxicity study dose levels of 500, 750 and 1000 mg/kg were administered daily for 28 days and compared with the control rats. In toxicity studies, no mortality and toxicity signs were observed. The MTD value was found to be more than 5000 mg/kg. Haematological and biochemical parameters were within the reference range, although AST was shown significant increase (p < 0.01) in the repeated dose oral toxicity study of the extract. The histopathological changes observed were restricted to vascular changes, inflammatory cells infiltration and degenerative changes in extract treated groups and were very mild to mild signs. The plant leaves showed significant anti-inflammatory and analgesic property that can be utilized to explore the therapeutic efficacy. Key words: Phyllanthus reticulatus, Phytochemical analysis, Anti-inflammatory activity, Toxicity study, Wistar albino rats.
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    ThesisItemOpen Access
    EVALUATION OF INVITRO ANTIMICROBIAL ACTIVITY OF Simarouba glauca ELECTROSPUN NANOFIBERS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2019-08) KANIKA SUDHAKAREN; KANIKA SUDHAKAREN; dr. JAGADEESH S. SANGANAL; dr. JAGADEESH S. SANGANAL
    The present study was conducted to synthesis nanofibers from methanolic leaves extract of Simarouba glauca by an efficient protocol of electrospinning technique using a mixture of Polyvinyl pyrrolidine and S. glauca extract in various concentrations viz, 8%, 12% and 14%.The phytochemical analysis of the plant extract were done and showed the presence of various secondary metabolites such as carbohydrates, proteins, alkaloids, flavonoids, tannins, phenolics, glycosides, anthraquinones, phytosterols and triterpenoids. The physico-chemical properties and the interaction between the plant extract and the polymer were analysed using SEM and FTIR. The invitro antibacterial activity of the plant extract nanofibers were studied by using Kirby- Bauer disc diffusion assay. Results obtained from the study indicates that the synthesised plant extract nanofibers possess antibacterial property against food spoilage microorganisms. Also found that when the plant extract concentration in the nanofibers increased, the antibacterial property was increased. Hence, it was concluded that extract can be used as source of natural antimicrobial compou
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    ThesisItemOpen Access
    EVALUATION OF INVITRO ANTIMICROBIAL ACTIVITY OF Simarouba glauca ELECTROSPUN NANOFIBERS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2019-08) KANIKA SUDHAKAREN; Dr. JAGADEESH S. SANGANAL
    The present study was conducted to synthesis nanofibers from methanolic leaves extract of Simarouba glauca by an efficient protocol of electrospinning technique using a mixture of Polyvinyl pyrrolidine and S. glauca extract in various concentrations viz, 8%, 12% and 14%.The phytochemical analysis of the plant extract were done and showed the presence of various secondary metabolites such as carbohydrates, proteins, alkaloids, flavonoids, tannins, p
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    ThesisItemOpen Access
    PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF VITEX NEGUNDO IN RATS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2017-08) PURANDAR B KAMBLE; Dr. N. B. SHRIDHAR
    The present study was conducted to evaluate various pharmacological and toxicological properties of the Vitex negundo extract. Phytochemical analysis revealed the presence of carbohydrates, glycosides, flavonoids, phenolics, tannins, Phytosterols, triterpenoids. Acute oral and sub-acute toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 401 and 407 respectively. In acute toxicity study, the LD50 cut off value was found to be more than 5 g/kg. No mortality and toxicity signs were observed. In sub acute toxicity study, methanol extract was administered @ 500, 1000, 2000 and 5000 mg/kg respectively and compared with the control rats. The results of body weight, gross and histopathological observations of the treated groups indicated the non toxic nature of the extract even @ 5000 mg/kg. In in vivo anti-inflammatory study of methanol extract, in carrageenan induced rat paw edema model, the extract @ 500 and 1000 mg/kg showed significant inhibition of rat paw edema in dose dependent manner indicating its anti inflammatory activity