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2008 - 200912010 - 20171
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Subject: Veterinary Pharmacology × End date: 2018 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF VITEX NEGUNDO IN RATS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2017-08) PURANDAR B KAMBLE; Dr. N. B. SHRIDHAR
    The present study was conducted to evaluate various pharmacological and toxicological properties of the Vitex negundo extract. Phytochemical analysis revealed the presence of carbohydrates, glycosides, flavonoids, phenolics, tannins, Phytosterols, triterpenoids. Acute oral and sub-acute toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 401 and 407 respectively. In acute toxicity study, the LD50 cut off value was found to be more than 5 g/kg. No mortality and toxicity signs were observed. In sub acute toxicity study, methanol extract was administered @ 500, 1000, 2000 and 5000 mg/kg respectively and compared with the control rats. The results of body weight, gross and histopathological observations of the treated groups indicated the non toxic nature of the extract even @ 5000 mg/kg. In in vivo anti-inflammatory study of methanol extract, in carrageenan induced rat paw edema model, the extract @ 500 and 1000 mg/kg showed significant inhibition of rat paw edema in dose dependent manner indicating its anti inflammatory activity
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    ThesisItemOpen Access
    TOXICITY STUDIES OF FUNGAL ISOLATES IN RATS AND MICE FROM PADDY STRAW SUSPECTED TO CAUSE NECROSIS OF EXTREMITIES IN BUFFALOES
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2008-07) SHIVAPRASAD, G. R.; N. B.«SHRIDHAR; K. JAYAKUMAR; H. D. NARAYANASWAMY; (S. G. RAMACHANDRA; S. YATHIRAJ
    In most developing countries, livestock production is an important part of national economy. A major constraint for increased milk production by small and medium dairy farmers is the chronic shortage of affordable feeds of adequate quality and quantity, particularly during the dry season. The problem of feed storage is further complicated by farmer’s inability to use them before they spoil, especially during wet season when there is a production peak. During peak production, one of the major agents of feed spoilage, are moulds. Though their prevalence and rate of colonization are highly dependent on climate and farm practices, the growth of moulds in raw material and finished feeds of livestock is an universal problem. Mould spores, of the so called field fungi, can contaminate cereal grains and stover in standing crop in severe conditions (too wet or too dry season). These include species of Fusarium, Altemaria, Cladosporium, Diplodia, Gibberella and Helminthosporium, their spores can germinate, especially under high moisture conditions (20-21%). The moulds can also c olonize on feed ingredients and feeds during storage especially with Aspergillus and Penicillium species at 13-18% moisture. Both field and storage fungi can result in elaboration of mycotoxins.