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Subject: Veterinary Pharmacology × Author: Revanasiddappa × Start date: 2006 ×
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    ThesisItemOpen Access
    Revanasiddappa
    (KVAFSU, Bidar, 2019) Revanasiddappa
    The study was taken up to evaluate the pharmacological and toxicological property of Phyllanthus reticulatus plant. Phytochemical analysis revealed the presence of carbohydrates, starch, flavonoids, phenolic compounds, tannins, saponins, phytosterols and triterpenoids. The study was conducted to evaluate the in vivo anti-inflammatory and analgesic property of the plant extract using carrageenan induced paw oedema and acetic acid induced writhings as peripheral pain model respectively and selected dose levels of pant extract are 50, 100 and 200 mg/kg. This revealed significant (p < 0.05 or p < 0.01) anti-inflammatory and analgesic activity at 100 and 200 mg/kg. Acute oral and repeated dose 28 day oral toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 423 and 407 respectively. In acute toxicity a dose levels of 300, 2000 and 5000 mg/kg were studied. In repeated dose 28 day oral toxicity study dose levels of 500, 750 and 1000 mg/kg were administered daily for 28 days and compared with the control rats. In toxicity studies, no mortality and toxicity signs were observed. The MTD value was found to be more than 5000 mg/kg. Haematological and biochemical parameters were within the reference range, although AST was shown significant increase (p < 0.01) in the repeated dose oral toxicity study of the extract. The histopathological changes observed were restricted to vascular changes, inflammatory cells infiltration and degenerative changes in extract treated groups and were very mild to mild signs. The plant leaves showed significant anti-inflammatory and analgesic property that can be utilized to explore the therapeutic efficacy. Key words: Phyllanthus reticulatus, Phytochemical analysis, Anti-inflammatory activity, Toxicity study, Wistar albino rats.