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ThesisItem Open Access PATHOLOGICAL STUDIES OF OCHRATOXICOSIS AND ITS AMELIORATION USING DIATOMACEOUS EARTH AND VITAMIN E IN BROILER CHICKENS(KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2016-05) DHEERENDRA NAIK; M. L. SATYANARAYANA; G. V. SUDHAKAR RAO; H. D. NARAYANASWAMY; SUGUNA RAO; S. YATHIRAJ; S. G. RAMACHANDRAThe study was conducted to evaluate the pathological and immunosuppressive effect of ochratoxin (OA) in broiler chicken and its amelioration using diatomaceous earth (DAE). Experimental ochratoxicosis was induced in broilers with 1 ppm and the ameliorating effects of DAE @ 2000mg/kg feed and Vitamin E 80ml/kg of feed was studied for 35 days. Feeding of ochratoxin caused significant reduction in the body weight gain and feed efficiency. Supplementation of DAE and Vitamin E showed improvement in performance parameters. Ochratoxicosis showed significant increase in relative weights of liver, kidneys and spleen whereas, the weights of bursa of Fabricius and thymus was reduced. Significant improvement in the organ weight was observed in DAE Vitamin E and their combinations supplemented birds. The serum levels of total protein and albumin were significantly lowered whereas, creatinine, AST, ALT and ALP were higher in toxin fed birds. The HI titres against NDV and antibodies against IBD, DAE and Vitamin E supplementation showed improvement in HI titre, against ND and antibodies against IBDV. Microscopic lesions, characteristic to ochratoxicosis were prominent in kidneys, liver and lymphoid organs. Supplementation of DAE and Vitamin E reduced the severity of lesions in these organs. Dietary inclusion of ochratoxin caused hepato-renal and immunotoxicity in birds. However, supplementation with DAE and Vitamin E was helpful in ameliorating the adverse effects of ochratoxicosis in broilers.