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Subject: Veterinary Pathology × Author: BHARATH KUMAR, K. × Start date: 2010 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON INDUCED DIABETES IN RATS WITH SPECIAL EMPHASIS ON COMBINED EFFICACY OF GYMNEMA SYLVESTRE AND SWERTIA CHIRAYITA EXTRACTS
    (KARNATAKA VETERINARY, ANIMAL AND FOISHERIE'S SCIENCES UNIVERSITY, BIDAR, 2020-01) BHARATH KUMAR, K.; Dr. SUGUNA RAO
    The present study was undertaken to evaluate the antidiabetic efficacy of Gymnema sylvestre and Swertia chirayita in combination with or without glibenclamide in streptozotocin induced diabetes in rats. The various groups in this study included normal control (Group I), diabetic control (Group II), diabetic rats treated with glibenclamide (Group III) at 600 μg/kg bw, diabetic rats treated with combination of Gymnema sylvestre and Swertia chirayita (Group IV) at 200 mg/kg bw each and diabetic rats treated with a combination of herbal extracts along with glibenclamide (Group V) at 100 mg/kg bw each and 300 μg/kg bw respectively. There was a significant improvement in the evaluatory parameters such as body weights, serum glucose, ALT, AST, cholesterol, triglyceride, blood parameters and hepatic antioxidant enzymes in treatment groups when compared to diabetic control. Histopathology and immunohistochemistry of pancreas also showed an improvement in the number of islet and β cells by 45th day in the treatment groups compared to diabetic control. Glibenclamide treatment substantially alleviated the effects of STZ in diabetic rats. However, the improvement was not on par with that of normal control rats. Combination of Gymnema sylvestre and Swertia chirayita with or without glibenclamide treatment only partially alleviated the STZ induced diabetic effects. Among the treatment groups, combination of herbal extract along with the glibenclamide at half dose showed better antidiabetic effect. No synergistic and no dose-dependent improvement was observed in the combination of Gymnema sylvestre and Swertia chirayita extract treatment. Combination of herbal extracts showed only mild antidiabetic effect hence cannot replace conventional anti diabetic treatment with glibenclamide. Key words: Diabetes, Gymnema sylvestre, Swertia chirayita, glibenclamide, streptozotocin, rats, immunohistochemistry