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ThesisItem Open Access Effect of Mimosa pudica (Lajvanti) and Melia azedarach (Bacain) on clinical cases of gastric ulcers in dogs(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2004-08) Pankaj Kumar; Sharma, V.K.In the present study therapeutic efficacy of Mimosa pudica (Lajwanti) and Melia azedarach (Bacain) alone and in combination was evaluated in sixteen confirmed clinical cases of canine gastric ulcer. The efficacy of treatment was judged on the basis of clinical symptoms, haematological, biochemical and radiological examinations. Excessive salivation, inappetance, dullness, depression, and pain on palpation in left epigastric region were observed as major clinical symptoms of gastric ulceration in these dogs. The animals with gastric ulcer passed black/chocolate coloured faeces of soft consistency. The mucous membrane of all animals was observed pale. The extremities were cold. In most of the cases, owners complained that bouts of vomition were observed soon after feeding. In most of the cases vomitus was of brownish in colour. All the clinical symptoms observed in the patients revealed mild to moderate clinical recovery within 10-12, 3-7, 5-7 and 3-5 days following treatment in group A, B, C and D respectively. Delayed reaction of skin tenting, decreased haemoglobin, lower PCV, higher TLC level, initial neutrophilia, lymphopenia and presence of occult blood in faeces were the constant feature of every animal under this experiment. On biochemical examination hyponatremia and hyperkalemia was the prominent feature. Mucosal damage and gastric hemorrhage were detected through the pH of gastric content and colouration of the vomitus. An increased level of gastric pH with pinkish to brownish colour was observed in all groups of animals on day 0. On contrast radiographic examination retention or adherence of contrast material with gastric mucosa and delayed gastric emptying were the constant features. Thus, on the basis of comparative evaluation of clinical, haematological, biochemical and radiological parameters of Group B and C, it can be concluded that Mimosa pudica is a marginally better drug than Melia azedarach in gastric ulcer healing in dogs. However, as per the present day information, possible mechanism of action of these herbal drugs may be due to their ability to be a coating agent, motility modifiers, antimuscarinic effect, H2-receptor antagonist and prostaglandin analogue or proton pump inhibitor. Their definite mode of action in these lines is to be investigated further.ThesisItem Open Access Effect of Mimosa pudica (Lajvanti) and Melia azedarach (Bacain) on clinical cases of gastric ulcers in dogs(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2004-08) Pankaj Kumar; Sharma, V.K.