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Subject: Veterinary Medicine × Author: Negi, Anjali × End date: 2024 × Start date: 2020 × Type: Thesis ×
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    ThesisItemOpen Access
    Assessment of antibacterial activity of Nyctanthes arbor-tristis leaves in clinic therapeutic management of salmonellosis in poultry
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2021-08) Negi, Anjali; Prasad, Amit
    The present study was conducted to assess the antibacterial activity of hydromethanolic extract of Nyctanthes arbor-tristis leaves in clinico therapeutic management of salmonellosis in poultry. An inhibition zone of around 14 mm was seen around disc impregnated with 500 mg/ml concentration of plant extract against Salmonella Typhimurium. A total of 80, day old broiler chicks were procured and divided into 4 groups (I to IV) with 20 chicks in each group. Group I served as healthy control without any infection and treatment. Group II was kept as infected control. At 8 day old of age, birds of group II, III and IV were challenged with 3x109 CFU/ml of Salmonella Typhimurium. Birds in group III and IV were treated with antibiotic (ofloxacin) and hydromethanolic extract of Nyctanthes arbor-tristis leaves in drinking water respectively. Growth performance, clinical signs, mortality rate, haematological and biochemical parameters were recorded to evaluate the antibacterial efficacy of herbal extract. Clinical signs and mortality rate were less severe in antibiotic and extract treated group than infected control group. Extract treated group had better FCR, weight gain and feed intake than infected control group. Among the hematological parameters, higher values of TLC and heterophils and lower lymphocyte percent were recorded in infected control group. Heterophil count was higher in extract supplemented group than antibiotic group whereas lymphocyte percent in both treatment groups was similar to healthy control group. Biochemical studies revealed no significant difference in total protein, albumin and globulin level in both treatment groups at 14 and 21day post infection. Higher ALT and AST values were observed in infected control group. Plant extract treated group had significantly lower ALT and AST values than ofloxacin treated and infected control group. It was therefore concluded that supplementation of herbal extract in drinking water was effective in controlling Salmonella Typhimurium infection as it not only controlled infection but also improved growth performance, alleviated clinical signs, showed hepatoprotective activity and also resulted in lesser mortality rate.