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Subject: Veterinary Medicine × Author: Kalita, Jyoti Chanda × End date: 2024 × Start date: 2020 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    Clinico-diagnostic findings of canine parvovirus infection and its therapeutic management with special reference to faecal microbiota transplantation
    (G. B. Pant University of Agriculture and Technology, Pantnagar, 2022-07) Kalita, Jyoti Chanda; Amit, Prasad
    The present research work “clinico-diagnostic findings of canine parvovirus infection and its therapeutic management with special reference to faecal microbiota transplantation” was carried out in the Department of Veterinary Medicine and Dr. I. P. Singh Veterinary Clinical Complex and Trauma Centre, C.V.A.Sc., G. B. Pant University of Agriculture and Technology, Pantnagar, Udham Singh Nagar, Uttarakhand between October 2021 and March 2022 for a period of 6 months. In addition, an epidemiological study of Canine Parvovirus in and around Pantnagar was performed between June, 2021 and June, 2022 for a period of one year. The prevalence study comprised 2068 cases of the total canine population out of which 627 animals (30.32%) had clinical indication of gastroenteritis. On the basis of screening by Rapid Antigen Test and confirmation by conventional PCR, 258/627 (41.15%) cases were found to be positive for Canine Parvovirus. The breed wise prevalence of Canine Parvovirus breed wise was found to be highest in mongrels (51.16%), followed by exotic breeds such as Labrador retriever (9.68%), German Shepherd (8.53%) and Rottweiler (8.14%) respectively. Out of 258 cases positive for Canine Parvovirus, the males were more affected as compare to the females. The prevalence of CPV was maximal in the age group of 3-6 months (43.41%), followed by pups of less than 3 months of age (31.40%), 6-12 months year group (20.93%) and >12 months year group (4.26%) respectively. The clinical cases presented had history of Anorexia, lethargy, dyspnoea, continuous vomiting and diarrhoea which is mostly haemorrhagic in nature, either pyrexia or hypothermia. Respiration rate and rectal temperature were non- significantly increased; whereas heart rate was significantly increased in the affected group as compared to the healthy control group. Significant decline in levels of haemoglobin, PCV, TEC, TLC, Neutrophils (%) while significant increase in Lymphocytes (%) was evident in the initial stage which returned to normal with recovery. The Overall results of the present study shows that the dogs of therapeutic groups were having hypoproteinaemia, hypoglobulinaemia, hypoalbuminemia, hyponatremia, increased ALP, AST, BUN, levels as compared to the healthy control group of dogs. Arrhythmias were found in 14.34% of affected dogs, with sinus tachycardia, supraventricular tachycardia, short PR intervals, deep negative T waves being the foremost common. From the comparative management of canine parvoviral enteritis, it was established that, group treated with faecal microbiota transplantation along with symptomatic therapy showed remarkable improvement in terms of resolution of diarrhoea i.e., 4/6 (66.67%) cases within 48 hours of therapy. All (100%) dogs were managed with symptomatic treatment according to the clinical signs observed.