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ThesisItem Open Access Evaluation of protective efficacy of Phyllanthus emblica and Curcuma longa in gout induced broilers(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2020-09) Bawari, Neha; Rajora, V.S.The present research work was conducted to study the clinicophysiological, hematobiochemical and histopathological alterations in birds due to gout and to evaluate therapeutic efficacy of allopurinol and combination of powder of amla and haldi on sodium bicarbonate induced gout. On the basis of pilot study and literature, sodium bicarbonate at the dose rate of 15g/l in drinking water was used to induce gout in broilers in the main trail. Group I was kept as control and fed with basal diet and normal water. Group II was kept sodium bicarbonate control (gout positive control) and dose of sodium bicarbonate @ 15 g/l was administered in drinking water daily for 35 days. Group III received with sodium bicarbonate along with allopurinol at the dose rate of 25 mg/kg BWt by oral gavaging daily once for 35 days. Group IV received only allopurinol at dose rate of 25 mg/kg BWt by oral gavaging for 35 days. Group V was treated with sodium bicarbonate along with combination of powder of Amla @ 3.75g/kg feed and Turmeric @ 3.75g/kg feed (0.375% each) mixed in feed for 35 days. Group VI were given combination of powder of Amla and Turmeric alone @ 3.75g/kg feed each mixed in feed for 35 days. Growth parameters were studied at weekly intervals where significant decreased in body weight, body weight gain and feed intake was recorded in group II however FCR was increased significantly throughout the experiment. Blood and tissue sampling was done on 15 and 35 DE, which revealed significant increase in Hb, PCV, TEC, ESR and MCV throughout the experiment in gout positive control group II. Biochemical parameters also revealed significant rise in uric acid, creatinine, BUN, ALT, AST, ALP, serum Na+, serum MDA and kidney XOD whereas significant reduction in serum K+ and P+ level in group II. Birds in the group II were dull, depressed, sleepy appearance, faced difficult in standing with swollen hock and revealed watery diarrhea and pasted vent. Gross and histopathological examination revealed typical sign of visceral gout like deposition of mono sodium urate crystals on different visceral organs and in some birds articular gout was also observed. Allopurinol and combination of amla and haldi powder alone or along with sodium bicarbonate revealed significant improvement in the above parameters which indicate ameliorative effects of allopurinol and combination of powder of amla and turmeric on gout. However, efficacy of both the treatment was found almost similar in sodium bicarbonate induced gout. Hence, it was concluded that combination of amla and turmeric powder was highly efficient in alleviating toxic effects of sodium bicarbonate induced gout in broilers and was comparable with standard drug allopurinol.