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ThesisItem Open Access Body adiposity, leptin and serum throtropin association in euthyroid premenopausal women(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-11) Gupta, Soumya; Raghuwanshi, Rita SinghThe present cross-sectional, population-based study was conducted among euthyroid premenopausal women (mean age 25.7 ± 3.2 years, mean BMI 24.87 ± 3.3 kg/m2) to investigate the association of degree of obesity and serum leptin with the serum thyrotropin concentration. Eighty-one healthy euthyroid premenopausal women, (26 normal and 55 overweight and obese subjects, as per BMI) with no known selfreported history of thyroid dysfunction, were studied. The mean energy intake of the study population was 83.5% of the RDA and the mean PAL revealed that majority of the study respondents perform sedentary activity. Notably, a considerable number of subjects showed high mean values of body fat percent i.e. ≥30% (61.7%) indicating generalized obesity and waist circumference at ≥73.50 cm (71.6%) indicating abdominal obesity. The study population also exhibited a high prevalence of subcutaneous adiposity (59.3%) and intra-abdominal (40.7%) adiposity. Out of the various anthropometric indices used to determine obesity in the study population with body fat percent as ‘standard’, BMI and WHtR displayed high sensitivity and lower misclassification rate at the optimal cutoff points of ≥23.1 kg/m2 (Sens. 98%, Spec. 80.6%) and ≥0.47 (Sens. 94%, Spec. 90.4%), respectively in the ROC curve analysis. Uncomplicated euthyroid overweight and obese premenopausal women showed increased (p<0.001) serum leptin (37.31±12.4 vs 10.39±4.9 ng/ml) and moderately elevated TSH levels (3.45±1.1 vs 0.90±0.4 mIU/L) than normal subjects. Evidently, a substantial number of subjects who were obese displayed TSH distribution in the third [2.44-4.05 mIU/L (46.3%)] and fourth quartile [4.06-5.40 mIU/L (43.9%)]. The proportion of subjects with TSH distribution in upper quartiles significantly (p<0.001) increased with increasing quartiles of leptin and with the increase in abdominal, subcutaneous and intra-abdominal adiposity. The relationship of dietary intake and physical activity status of the study population was also assessed with TSH. TSH correlated significantly and positively with leptin (r=0.66); body weight (r=0.45); BMI (r=0.67); body fat percent (r=0.73); subcutaneous adipose tissue (r=0.60); intra-abdominal adipose tissue (r=0.53); waist circumference (r=0.59); hip circumference (r=0.42); neck circumference (r=0.28); BMR (r= 0.25) and negatively with physical activity level (r= -0.34) in overweight and obese euthyroid subjects. In a multivariable regression analysis, BMI (β=0.84), body fat percent (β=0.52), total abdominal fat (β=0.72) and leptin (β=0.31) associated significantly with serum TSH after adjusting for various variables. Considering the clinical evidence provided by this observational study, it may possibly be implied that a direct relationship exists between grades of obesity and TSH and that leptin might be the possible link between thyroid function and adiposity which may stimulate the rise in TSH directly or indirectly to regulate the thermogenesis in obesity.ThesisItem Open Access Development and quality evaluation of composite grain khakhra and its glycemic index(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-09) Shukla, Swati; Awasthi, PratimaThesisItem Open Access Assessment of quality characters of whole, dehulled and split cowpea (Vigna unguiculata (L.) Walp) and its husk(2017-06) Suri, ShwetaCowpea (Vigna unguiculata (L) Walp) is a legume belonging to family Fabaceae and genus Vigna. Cowpea is a nutritious legume and also a good source of protein. Keeping in view the advantages of cowpea seeds, the Pant lobia -5 seeds were taken for the present study. Pant lobia-5 seeds was subjected to different processing techniques (Dehulling and splitting) so as to increase its consumption among the Indian population. The nutritional quality of cowpea seeds including proximate composition was analyzed. Also the micronutrient content such as iron, magnesium, zinc and calcium and amino acid content such as methionine, tryptophan and lysine content of cowpea seeds was analyzed. The dietary fibre and antioxidant activity such as total phenol, total flavonoid content and total antioxidant activity was also analyzed. The sensory evaluation of different processed forms of cowpea dal and storage stability of cowpea seeds was also done. It can be concluded from the present study that the cowpea variety (Pant lobia-5) is a nutritious legume. The study establishes that cowpea seeds can also be utilized in dehulled and split forms besides the traditional use as whole cowpea seed. Dehulling of cowpea seeds has emerged as a better processing technique as compared to splitting because the protein and specifically the tryptophan content increases due to this process. The storage studies of processed cowpea seeds further showed that processing does not bring about a significant change in the storage stability of the processed cowpea seeds upto six months when stored in air tight plastic container. Sensory evaluation of the differently processed cowpea showed that dehulled cowpea dal had the highest acceptance. It emerges from the study that dehulled cowpea seeds are nutritionally and organoleptically superior to split and whole cowpea seeds.ThesisItem Open Access Development of foxtail millet instant vermicelli(2017-06) Kharkwal, Vineeta; Srivastava, SaritaThesisItem Open Access Suitability of finger millet & barnyard millet incorporated pizza base in diabetes and cardiovascular diseases(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-06) Shrestha, Renu; Srivastava, SaritaThe present study was conducted to evaluate glycemic index and hypolipidemic effect of finger millet incorporated pizza base and barnyard millet incorporated pizza base. Finger millet variety PRM-15 and barnyard millet variety PRJ-1 were taken for the study. Results on physical properties showed higher values for thousand kernel weight (3.18 g) and thousand kernel volume (3.93 ml) of barnyard millet, while finger millet showed higher values for bulk density (0.94 g/cc), hydration capacity (0.064 %) and total flour recovery (68.58 %). The results on functional properties showed that barnyard millet flour had significantly higher water absorption (158.63 ml/100g), fat absorption (146.67 ml/100g) and sedimentation value (13.30 ml), while refined wheat flour had significantly higher emulsion activity (42.99 %), emulsion stability (40.70 %), dough raising capacity (92.54 %) and wet and dry gluten content (26.42 and 9.22 %, respectively). Each of finger millet flour and barnyard millet flour blends with refined wheat flour (30:70, 40:60, 50:50, 60:40) showed gradual increase in water absorption and fat absorption with increase in millet flour incorporation. The other functional properties showed declining trend with increased incorporation of millet flour. Nutrient analysis of finger millet and barnyard millet indicates that the finger millet had significantly higher amount of moisture (12.08 %), total ash (2.43 %), crude protein (12.39 %), calcium (276.03 mg%), total dietary fiber (14.68 %) and antioxidant activity (68.33 %), while barnyard millet had significantly higher level of crude fat (3.50 %), crude fiber (7.51 %), phosphorus (204.12 mg%) and zinc (4.91 mg%). Texture profile analysis of the products showed that the finger millet incorporated pizza base had significantly higher hardness (281.60 N) and gumminess (131.39 N), while barnyard millet incorporated pizza base had significantly higher values for chewiness (153 N x mm). Finger millet incorporated pizza base showed significantly higher amount of total ash (1.77 %), crude protein (11.08 %), calcium (183.88 mg%), total dietary fiber (10.98 %) and total antioxidant activity (43.44 %), while barnyard millet incorporated pizza base contained significantly higher amount of moisture (30.40 %), crude fat (6.17 %) and crude fiber (3.58 %). Finger millet incorporated pizza base and pizza showed low glycemic index value (36.23 and 46.05, respectively) and did not differ significantly from barnyard millet incorporated pizza base and pizza (36.67 and 43.43, respectively). The experiment on albino rats showed the hypolipidemic effect of finger millet incorporated and barnyard millet incorporated pizza base measured in terms of serum total cholesterol, triglyceride, HDL, LDL and VLDL level. Therefore it can be concluded that both finger millet incorporated and barnyard millet incorporated pizza base are suitable for prevention and control of diabetes and cardiovascular diseases.ThesisItem Open Access Optimization and quality evaluation of beetroot enriched nutritious snack bar(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-06) Tangariya, Priyanka; Awasthi, PratimaThesisItem Open Access Quality evaluation of improved varieties of field pea (Pisum sativum) seed flour & product development(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-06) Goswami, Kanchan; Shukla, PushpaThesisItem Open Access Quality evaluation of black and yellow soybean (Glycine max (L.) Merill) for nutrients, dietary fiber, antioxidants, antinutritional factors and glycemic index(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-06) Tewari, Gunjan; Raghuwanshi, Rita SinghThesisItem Open Access Formulation and quality evaluation of multigrain bun(G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-06) Sahoo, Anushriya; Awasthi, Pratima