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2017 - 201912020 - 20211
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Subject: Chemistry × Author: Tamta, Garima × End date: 2021 ×
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    ThesisItemOpen Access
    Phytochemical and pharmacological activities of Ficus auriculata leaf, bark and fruit from different agro-climatic conditions of Uttarakhand
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2021-02) Tamta, Garima; Tandon, Shishir
    The present investigation conducted on fruits, leaves and bark of Ficus auriculata (Timul) collected from two agro-climatic conditions of Uttarakhand (Haldwani and Almora). Extract were done by successive soxhlet extraction method by three solvents viz. methanol, chloroform and hexane. Presence of alkaloids, terpenoids, saponins, fatty acids and glycosides were estimated by preliminary test. Phytoconstituent evaluated by GC-MS analysis showed various phytoconstituents in all extract. Some majore constituents were identified ƴ-sitosterol , lupeol, linoleic acid (methyl ester), kinic acid, phytol, oleic acid(methyl ester) and squalene. Several other fatty acids with minor phytoconstituents were also identified. Phenolics, Flavonoids, orthodihydric phenol, proanthocyanidin and tannin content were also found in good quantitiy. Fruits , leaves and bark were rich in nutritional potential including moisture, ash, crude fibre, crude fat, crude protein and carbohydrate contents. Elemental analysis were done by AAS to know micronutrients in plants and their quantity were present in the following order-: K>Mg>Ca>Fe>Ni>Na>Cu>Mn>Cr>Co. Antioxidant activity were done and the highest DPPH radical scavenging activity and hydroxyl radical scavenging activity were exhibited by AUFME (IC50 =447.45±0.53μg/ml) and (IC50 =463.7±1.55μg/ml) respectively. HRFHE exhibited maximum nitric oxide and super oxide radical scavenging activity (IC50 =487.5±1.82 μg/ml) and (IC50 =508.94±0.754 μg/ml) respectively. ARFHE exhibited maximum metal chelating activity (IC50 =483.95±3.21 μg/ml) while FRAP assay was found maximum in ABHE (IC50 =8.15 ±0.742 μmole/g). Fruits, leaves and bark extracts in methanol, chloroform and hexane exhibited the effective antibacterial potential against gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram negative bacteria (Salmonella typhi and Escherichia coli). In antidiabetic activity, AUFME exhibited maximum alpha amylase and glucosidase inhibitory activity (IC50 =240.45±1.26 μg/ml) and (IC50 =245.02±1.81 μg/ml) respectively. HUFME showed the maximum anti-inflammatory activity (IC50 =536.89±1.79 μg/ml). Herbicidal potential were shown maximum by AUFCE and HBCE and root growth inhibition found greater than shoot growth inhibition.
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    ThesisItemOpen Access
    Chemo profiling of Achyranthes aspera
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-07) Tamta, Garima; Viveka Nand