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Subject: Chemistry × Author: Bhandari, Suneeta × End date: 2018 × Start date: 2018 × Thesis Type: Ph.D ×
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    ThesisItemOpen Access
    Development of green methodologies for the synthesis of some biologically active heterocyclic and β- amino carbonyl compounds
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2018-05) Bhandari, Suneeta; Kasana, Virendra
    A series of chromene, indenochromene, oxazolone and β-amino carbonyl compounds have been synthesized using mild catalytic systems. Camphor-10-sulphonic acid has been used as an efficient organo-catalyst for the synthesis of chromene and indenochromene compounds. Oxazolone derivatives have been synthesized using L-proline as an organocatalyst via aldol condensation reaction. Fe3+-montmorillonite K10 clay, a solid supported heterogeneous recyclable, efficient and environmentally benign catalytic system has been developed for the synthesis of β-amino carbonyl compounds. Ionic liquid supported on silica nanoparticles (SILnPs) has been developed as an efficient and economical solid supported recyclable catalyst for one-pot three component direct synthesis of β-amino carbonyl compounds via Mannich type reaction. The structures of catalytic systems have been characterized using SEM, TGA, powder XRD, FT-IR methods. The structures of synthesized compounds have been elucidated using FT-IR, 1H NMR, 13C NMR and single X-ray crystallography. Further, oxazolone derivatives were studied for herbicidal activity against Raphanus sativus. β-amino carbonyl were studied for herbicidal activity against weeds Melilotus alba and Lathyrus aphaca. Most of the tested compounds of these two classes were found to exhibit good herbicidal activity. β-amino carbonyl derivatives were also studied for antibacterial activity against two human pathogenic bacterial strains Escherichia coli and Bacillus subtilis. The compounds 3-((4-fluorophenyl)amino) -3-(3-methoxyphenyl)-1-phenylpropan-1-one (20f) and 3-((4-chlorophenyl)amino)-1,3-diphenylpropan-1-one (20h) were found to have good antibacterial activity.