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20211
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Subject: Chemistry × Author: Ajay Kumar × End date: 2021 × Start date: 2021 ×
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    ThesisItemOpen Access
    Studies on N-arylsulfonamides containing thiophene and chromene moieties for their synthesis and antibacterial activity
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2021-02) Ajay Kumar; Kasana, Virendra
    N-arylsulfonamide derivatives containing thiophene, chromene and benzoxazole substituted chromene moieties were synthesized. N-substituted amino derivatives containing thiophene moiety were prepared by multi-component reactions (MCR) of substituted benzaldehydes, benzyl cyanide, malanonitrile and sulfur using organic catalyst L-proline. Multi-component reaction of substituted benzaldehydes, phenol and malanonitrile were catalyzed by L-proline afforded N-substituted amine derivatives containing chromene moiety. Benzoxazole substituted chromene moiety containing amino derivatives were synthesized from starting materials malanonitrile and 2-amino phenol to afford 2-(benzoxazol-2-yl) acetonitrile which was further reacted to phenol and substituted benzaldehydes using L-proline as catalyst to afford amino derivatives. The L-proline has been used as organocatalyst for these reactions first time. All above mentioned three different classes of amino derivatives were reacted with p-toluene sulfonyl chloride to afford final amide products. The synthesized compounds were evaluated for their antibacterial activity against Salmonella typhinurium, Escherichia coli and Staphylococcus aureus pathogenic bacterial strains. Some derivatives of synthesized compounds exhibited good antibacterial activity at concentration 10,000ppm. The thiophene, chromene and benzoxazole substituted chromene compounds synthesized may further be modified to develop a class of potential antibacterial agents.