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Subject: Biochemistry × Author: Bhatt, Dheeraj × End date: 2019 × Start date: 2010 ×
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    ThesisItemOpen Access
    Screening and biological activities of various bioactive compounds in finger millet [Eleusine coracana (L.) Gaertn.] genotypes collected from various hilly regions of Uttarakhand
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-07) Bhatt, Dheeraj; Verma, K.C.
    Many food crops with high quality nutritional value growing in the Himalayan region have been in use from ancient time to treat various ailments in different traditional ways. In recent year, demand for high nutritional value crops has increased tremendously. The present study, focused on the Screening and Biological Activities of Various Bioactive Compounds of 10 different genotypes of Finger millet [Eleusine coracana (L.) Gaertn.], commonly known as Ragi, collected from different regions of Uttarakhand. The proximate composition showed variation in value for biochemical constituents like ash (2.58-3.18%), moisture (6.41-11.12%), protein (6.20-11.12%), fat (2.58-4.56%), tannin (1.12-4.71%), starch (35.71-41.57%), resistant starch (5.85-12.71%) and minerals (mg/100g) like as Ca (96.73-230.78), Mg (122.2-221.32), Mn (152.61-369.14) & Fe (0.147-9.44). The % yield in methanol extracts were range from 3.08-6.12% while 2.81-5.75% in hexane extracts. The range of total phenolic, total flavonoid, total antioxidant content, DPPH free radical scavenging activity, metal chelating activity of Fe2+, ferrous reducing antioxidant power , in-vitro antiinflammatory activity in methanol were 3.17-5.01 mg GAE/g, 0.76-1.72 mg CE/g, 39.02-85.98 mM AA/mg, 43.37-48.84%, 20.73-35.78%, 30.91-109.38 μg BHTE/mg and 38.98-73.75% respectively whereas in hexane, the range were 1.76-3.16 mg GAE/g, 0.511-1.29 mg CE/g, 30.31-72.41 mM AA/mg, 27.48-42.8%, 17.34-31.47%, 16.21-83.72 μg BHTE/mg and 21.99-64.77% respectively. The seed extract analysis by GC-MS reveled active components that show all sort of pharmacological activities from antioxidants to anti-cancerous. Out of all genotypes, the genotype which was collected from Bageshwer, shows better activity in terms of biochemical compositions like fat, tannin, starch & resistant starch contents as well as in antioxidant potential like TPC, TFC, TAA and ferrous chelating activity followed by Dwarahat genotype which was good in term of mineral composition (Ca, Mg & Fe) and also shows better ferrous reducing antioxidant power and in-vitro anti-inflammatory activity. As finger millet has significant mineral composition and shows good antioxidant and anti-inflammatory activity, it might be envisage as an alternate source of staple crop and natural soruce of antioxidant and anti-inflammatory agent.