Thumbnail Image

Thesis

Browse

20211
Reset filters
Subject: Zoology × Author: Ramandeep Kaur × Start date: 2020 × Type: Thesis ×
Reset filters

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    ThesisItemOpen Access
    Hepatotoxicity and nephrotoxicity caused by combination of arsenic, cadmium and lead heavy metal and its amelioration by curcumin and ascorbic acid in male albino rats
    (Punjab Agricultural University, Ludhiana, 2021) Ramandeep Kaur; Navdeep Kaur
    The hepatotoxicity and nephrotoxicity caused by mixture of As, Cd and Pb in drinking water and its amelioration with curcumin and ascorbic acid was studied in male albino rats. The histopathological studies showed changes in architecture of liver and kidney tissues of heavy metals treated rats as compared to control rats and curcumin and ascorbic acid showed a restored structure of liver and kidneys. There was a significant (p<0.05) decrease in proteins, lipids, catalase (CAT), superoxide dismutase (SOD) activities and significant increase in cholesterol, phospholipids, fatty acids and malondialdehyde level (MDA) in liver and kidneys and a significant increase in activities of alanine and aspartate aminotransferase (ALT and AST), acid and alkaline phosphatase (ACP and AKP) as well as urea, creatinine in plasma of heavy metals treated rats at 60 and 90 days. The liver of rats treated with heavy metals, curcumin and ascorbic acids showed non-significant variation of proteins, lipids, cholesterol for 60 days only and MDA , activities of SOD, catalase in liver as well as activities of plasma enzymes such as ACP, AKP, ALT, AST for 60 and 90 days .The rats treated with heavy metals, curcumin and ascorbic acids showed non-significant variation of MDA, plasma urea for 60 days and proteins, lipids, cholesterol, phospholipid, fatty acids, activities of SOD , catalase in kidneys as well as plasma creatinine for 60 and 90 days. Thus, curcumin and ascorbic acid have the ameliorating potential against hepatoxicity and nephrotoxicity caused by mixture of heavy metals in drinking water.