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Synthesis and antifungal activity of Mannich bases and their transition metal complexes
(Punjab Agricultural University, Ludhiana, 2016) Manpreet Kaur; Manpreet Kaur
In the present work Mannich base ligands and their transition metal complexes with Cr(III), Fe(III), Zn(II), Cu(II), Co(II) and Ni(II) salts were synthesized by ultrasonicator and conventional technique respectively. The crude products were purified by successive washings with ethanol and characterized on the basis of physical measurements and spectral studies. The antifungal activity of the synthesized compounds was screened in vitro against Bipolaris oryzae and Fusarium verticilloides using spore germination inhibition method in comparison with Propiconazole 25 EC taken as a standard to reveal the potency of the synthesized compounds. All the synthesized compounds possessed moderate antifungal potential. Most of the compounds have ED50 values significantly higher as compared to Propiconazole 25 EC. The observed trend for antifungal activity was: Mannich base ligands< Transition metal complexes< Propiconazole 25 EC. The increased activity of metal complexes can be attributed to enhanced lipophilicity on chelation.