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Synthesis, characterization and microbial activity of novel schiff bases of o-phenylenediamine
(Punjab Agricultural University, Ludhiana, 2017) Gaganpreet Kaur; Sharma, Sunita
Schiff bases are the subject of extensive interest due to their versatile applications and similarity of structure with natural biological compounds. N- substituted benzylidene benzene-1,2-diamines (I-V) and N, N'-bis substituted benzylidene benzene-1,2-diamines (VI-X) were synthesized by reacting different aldehydes with o-phenylenediamine in the presence of catalytic amount of sodium hydroxide (10%) by taking 1:1 and 2:1 molar ratio respectively. Physical data of all the synthesized compounds was recorded. All the compounds were characterized by their IR and 1H NMR spectra and were evaluated for microbial activity against Psuedomonas sp., Klebsiella sp., Burkholderia sp. and Fusarium oxysporum. at different concentrations. The N, N'-bis substituted benzylidene benzene-1,2-diamines were found to be more effective than N- substituted benzylidene benzene-1,2-diamines. The compound VIII with halogen substitution at para position was found to be more effective than all other compounds. The other halogenated compounds followed the order Br > Cl > F. All the compounds were found to be less effective than the standard ampicillin and carbendazim (bavistin) at all the concentrations.