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ThesisItem Restricted Synthesis and microbial activity of pyrazolines and their derivatives(Punjab Agricultural University, Ludhiana, 2014) Gaba, Jyoti; Sharma, SunitaClaisen Schmidt reaction of different aromatic aldehydes with acetone gave α,β-unsaturated ketones which on further reaction with hydrazine hydrate in the presence of glacial acetic acid afforded pyrazolines. Acids viz. acetic acid and propanoic acid were treated with thionyl chloride to give respective acid chlorides which were then reacted with synthesized pyrazolines using triethylamine as catalyst in dry dichloromethane to give respective Nacetylated pyrazolines and N-propanoylated pyrazolines. Pyrazolines and N-substituted pyrazolines were characterized by their IR, 1H NMR and 13C NMR spectra. All the synthesized pyrazolines and N-substituted pyrazolines were screened for their microbial activity against Bacillus sp., Pseudomonas sp., Acinetobactor sp. and Klebsiella sp. Pyrazolines having substitution on benzene ring exhibited lower MIC values than pyrazolines having no substitution on benzene ring for all tested bacteria. All pyrazolines and Nsubstituted pyrazolines exhibited less activity than standard ampicillin at all the tested concentrations. None of the compounds exhibited activity at 100 µg/ml and all the compounds showed significant differences among themselves at all the concentrations. All Nacetylated and N-propanoylated pyrazolines having substitution of methoxy group at meta position and hydroxy group at para position of benzene ring were found effective against Bacillus sp., Acinetobactor sp. and Pseudomonas sp. but not against Klebsiella sp. Some of the synthesized compounds showed promising to moderate activity against all the microbes.