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20172
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Subject: Clinical Veterinary Medicine, Ethics and Jurisprudence × End date: 2017 × Start date: 2017 ×
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    ThesisItemOpen Access
    CLINICO-PATHOLOGICAL AND THERAPEUTIC INVESTIGATIONS ON JAUNDICE IN DOGS
    (COLLEGE OF VETERINARY AND ANIMAL SCIENCE-MANNUTHY,THRISSUR, 2017-03-23) ABDUL LATHIEF., K A; Usha Narayana Pillai
    The present study on “Clinico-pathological and therapeutic investigations on Jaundice in dogs” was carried out in the department of Clinical Veterinary Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy during the period from February 2014 to June 2015. Twenty five dogs brought to the Teaching Veterinary Clinical Complex, Mannuthy and University Veterinary Hospital, Kokkalai with observable jaundice met the criteria for inclusion in the study. These animals were subjected to detailed clinicopathological evaluation and systematic ultrasonographic scanning of the abdomen. The haematological parameters evaluated included haemoglobin, total erythrocyte count, packed cell volume, total leucocyte count, differential leucocyte count and platelet count. Serum biochemical parameters included albumin, globulin, ALT, AST, ALP, GGT, creatinine, BUN, glucose and cholesterol. After diagnosis, the causes of Jaundice were classified into infectious and non-infectious. Among the cases studied, 44 per cent had leptospirosis, 32 per cent had Babesia canis, 12 per cent had Babesia gibsoni, 8 per cent had hepatic neoplasia and 4 per cent had a history of snake bite. The highest magnitude of rise in bilirubin was observed in hepatic neoplasia and lowest in Babesia gibsoni. Fourty eight per cent of the cases were observed in young age followed by thirty six per cent in the middle age and sixteen per cent in geriatric age. The mean total serum bilirubin in Leptospira affected animals were 5.18 ± 0.7. The disease was confirmed with dark field microscopy and MAT. A significant neutrophilic leucocytosis with thrombocytopenia, elevated liver enzymes and acute renal failure were consistent features. There was increased prevalence of Leptospira serovar australis followed by serovar autumnalis and serovar canicola. The mean total serum bilirubin in dogs affected with Babesia canis was 4.55 ± 0.56. Diagnosis was made by parasitological evaluation including blood smear examination. In dogs affected with Babesia gibsoni, the mean total serum bilirubin was 2.53 ± 0.36. Anaemia with thrombocytopenia, elevated liver enzymes and splenomegaly on ultrasonography were commonly observed features in babesiosis. The magnitude of increase in bilirubin was found to be maximum in hepatic neoplasia with a rise in total serum bilirubin upto 8.00 mg/dl in hepatocellular carcinoma and upto 13.10 mg/dl in metastatic tumour affecting the liver. The total serum bilirubin observed in Russell’s viper envenomation was 4.52mg/dl. Treatment of jaundice was directed at eliminating the specific etiology while allowing the jaundice to resolve by its own. Therapeutic response was evaluated based on improvement clinical and biochemical parameters along with whole blood and blood smear re-examination
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    ThesisItemOpen Access
    ECHOCARDIOGRAPHIC EVALUATION OF MALABARI GOATS WITH HAEMOPARASITIC DISEASES
    (COLLEGE OF VETERINARY AND ANIMAL SCIENCES-MANNUTHY,THRISSUR, 2017-10) TEJASWINI, K. G.; Madhavan Unny., N
    The study was carried out to establish standard echocardiographic values and indices for adult Malabari goats and to study echocardiographic changes in Malabari goats with haemoparasitic diseases. Twelve healthy non-pregnant adult Malabari goats from Goat and Sheep Farm, KVASU, Mannuthy aged one to two years and body weight ranging from 20-25 Kg were utilized to establish standard echocardiographic indices for Malabari goat. Twelve female Malabari goats presented to the University Veterinary Hospitals at Mannuthy and Kokkala which were positive for blood parasites constituted the diseased group. The affected animals were of similar body weight and age group as the control animals. Echocardiographic study included B and M-mode assessment for both the control and diseased group. Haemato-biochemical parameters namely total erythrocyte count, haemoglobin, volume of packed red cells and serum creatinine kinase-MB were assessed for both the groups. The standard echocardiographic values and indices obtained were Left Ventricular Internal Diameter at End Diastole and Systole (2.73 ± 0.07 cm and 1.66 ± 0.08 cm), Interventricular Septum at End Diastole and Sytole (0.80 ± 0.02 cm and 1.07 ± 0.02 cm), Left Ventricular free wall thickness at End Diastole and Systole (0.78 ± 0.02 cm and 1.33 ± 0.03 cm), Fractional Shortening and Ejection Fraction (40.78 ± 2.66 % and 71.61 ± 2.89 %) respectively. Left Atrium to Aortic ratio in B and M-mode were 1.07 ± 0.01 cm and 0.74 ± 0.02 cm. Out of twelve animals selected, nine were positive for Anaplasma spp., two were positive for Theileria spp. and one animal was positive for mixed infection of anaplasma and theileria. The normalized values of healthy animals were compared with cardiac dimensions of diseased animals. Significant difference was observed in the left atrium to aorta ratio in both B and M-mode of blood parasite affected animals in comparison to healthy animals. The haematological parameters were significantly lower than healthy animals. Serum creatine kinase-MB values were significantly elevated in affected animals. The study established the normal echocardiographic parameters in female adult Malabari goats. Variations in left atrium and aorta ratio and serum creatine kinase-MB values in affected animals suggested cardiac involvement in haemoparasitic diseases.