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ThesisItem Open Access CLINICO-PATHOLOGICAL AND THERAPEUTIC INVESTIGATIONS ON JAUNDICE IN DOGS(COLLEGE OF VETERINARY AND ANIMAL SCIENCE-MANNUTHY,THRISSUR, 2017-03-23) ABDUL LATHIEF., K A; Usha Narayana PillaiThe present study on “Clinico-pathological and therapeutic investigations on Jaundice in dogs” was carried out in the department of Clinical Veterinary Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy during the period from February 2014 to June 2015. Twenty five dogs brought to the Teaching Veterinary Clinical Complex, Mannuthy and University Veterinary Hospital, Kokkalai with observable jaundice met the criteria for inclusion in the study. These animals were subjected to detailed clinicopathological evaluation and systematic ultrasonographic scanning of the abdomen. The haematological parameters evaluated included haemoglobin, total erythrocyte count, packed cell volume, total leucocyte count, differential leucocyte count and platelet count. Serum biochemical parameters included albumin, globulin, ALT, AST, ALP, GGT, creatinine, BUN, glucose and cholesterol. After diagnosis, the causes of Jaundice were classified into infectious and non-infectious. Among the cases studied, 44 per cent had leptospirosis, 32 per cent had Babesia canis, 12 per cent had Babesia gibsoni, 8 per cent had hepatic neoplasia and 4 per cent had a history of snake bite. The highest magnitude of rise in bilirubin was observed in hepatic neoplasia and lowest in Babesia gibsoni. Fourty eight per cent of the cases were observed in young age followed by thirty six per cent in the middle age and sixteen per cent in geriatric age. The mean total serum bilirubin in Leptospira affected animals were 5.18 ± 0.7. The disease was confirmed with dark field microscopy and MAT. A significant neutrophilic leucocytosis with thrombocytopenia, elevated liver enzymes and acute renal failure were consistent features. There was increased prevalence of Leptospira serovar australis followed by serovar autumnalis and serovar canicola. The mean total serum bilirubin in dogs affected with Babesia canis was 4.55 ± 0.56. Diagnosis was made by parasitological evaluation including blood smear examination. In dogs affected with Babesia gibsoni, the mean total serum bilirubin was 2.53 ± 0.36. Anaemia with thrombocytopenia, elevated liver enzymes and splenomegaly on ultrasonography were commonly observed features in babesiosis. The magnitude of increase in bilirubin was found to be maximum in hepatic neoplasia with a rise in total serum bilirubin upto 8.00 mg/dl in hepatocellular carcinoma and upto 13.10 mg/dl in metastatic tumour affecting the liver. The total serum bilirubin observed in Russell’s viper envenomation was 4.52mg/dl. Treatment of jaundice was directed at eliminating the specific etiology while allowing the jaundice to resolve by its own. Therapeutic response was evaluated based on improvement clinical and biochemical parameters along with whole blood and blood smear re-examination