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ThesisItem Open Access Ascending coccygeal venography in evaluation of paraplega in dogs(Department of Surgery, College of Veterinary and Animal Sciences, Mannuthy, 2002) Joshi George; KAU; Sarada Amma, TThe study was undertaken with an objective of evaluating the comparative efficacy of ascending coccygeal venography and epidurography in locating the site and type oflesion in dogs suffering from paraplegia. The study was conducted in 12 clinical cases presented at the Surgery unit of Veterinary College Hospital, Mannuthy and were designated into two groups (Group A and B) of 6 animals each. Survey radiographs were taken in all the animals prior to the contrast radiographic procedures. Iohexol (300 mgIfrnl) was used as the contrast medium at a dose rate of 80 mgIlkg body weight for epidurography and 100 mgIlkg body weight for ascending coccygeal venography. In Group A, epidurography was conducted by introducing the contrast medium through the lumbosacral junction into the epidural space. The contrast medium was given as slow infusion and the zero minute radiograph was taken, as the last milliliter of the contrast medium remained to be injected. Subsequent radiographs were taken at the 3rd and the 5th minute. In Group B, ascending coccygeal venography was conducted by introducing the contrast medium intravenously as slow infusion into the superficial lateral coccygeal vein of anyone side near the base of the tail, after sufficient abdominal compression. Lateral/ventrodorsal radiographs were taken, as the last milliliter of the contrast remained to be injected. Subsequent radiographs were taken at the 3rd and the Sth minute. All the animals were subjected to a thorough clinical and neurological examination prior to radiography. Physiological and haematological parameters were evaluatedjust before and 24 hours after radiography. All the animals were observed for one week for the presence of any side effects/complications. The physiological and haematological parameters were within the normal range in all the animals both before and 24 hours after radiography. Iohexol was found safe for neuroradiological studies as none of the animals exhibited any side effects/complications during the period of observation for one week. In Group A, epidurography produced good quality radiographs and was consistent in all the six cases. Abnormalities/lesions could be located in four cases. The remaining two cases showed normal epidurographic pattern and could not be correlated with the neurological examination. In Group B, successful venograms were obtained in three cases in which lesions were located and correlated with the neurological examination. In the remaining three cases, the venous sinuses could not be opacified and hence failed in identification oflesion. The changes identifiable as lesions in Group A were attenuation of the contrast col W11l1 , considerable narrowing and elevation of the column, and failure of the opacification ofa specific region of the column. The changes identifiable with a lesion in venography were abrupt attenuation of the venous sinuses, considerable elevation of the venous sinuses and progressive thinning and attenuation of the veins. Thus epidurography showed consistency III all the SIX cases and diagnosis could be made in four out of six cases whereas diagnostic venograms were obtained only in three out of six cases. Thus ascending coccygeal venography was found inconsistent and required further studies before recommending this as a routine practice. Though epidurography possessed a distinct advan tage over ascending coccygeal venography in consistency and technical and diagnostic feasibility, epidurography couldnot be advocated as a sole diagnostic procedure and should be used as an adjunct with other .diagnostic aids after proper clinical and neurological examination.ThesisItem Open Access Clinical and serum biochemical evaluation in surgery for alimentary tract obstruction in dogs(Department of Surgery, College of Veterinary and Animal Sciences, Mannuthy, 2001) Shejo Jose; KAU; Rajankutty, KThe study was carried out in selected clinical cases of alimentary tract obstructions in twelve dogs of either sex and different breeds, presented to the clinics of the college. These animals were divided into two groups viz. Group I and Group II, each consisting of six animals. Group 1- Dogs with obstructions of upper alimentary tract (oesophagus, stomach, duodenum and jejunum). Group II - Dogs with obstructions of lower alimentary tract (ileum, caecum, colon and rectum). In Group I the obstructions were due to bone pieces, granite stone, cloth piece, partial torsion of stomach and pyloric stenosis. In Group II the obstructions were due to corkscrew, ileocolic intussusception, cloth pieces and faecoliths. The obstructions due to foreign bodies were 50 per cent, with faecoliths were 25 per cent and due to anatomical alterations and malpositions of gastrointestinal tract were 25 per cent. In upper alimentary tract obstruction (Group I), the predominant clinical sign was vomiting. Frequency of vomiting was more than four times a day and vomitus was either frothy or white in colour. Pain on abdominal palpation and constipation were the other symptoms noticed. Respiration rate, systolic and diastolic blood pressure, total leukocyte count, lymphocyte count and blood urea nitrogen, creatinine, total serum protein and serum albumin levels were higher than the normal range, preoperatively. The packed cell volume, total erythrocyte count, haemoglobin concentration and serum sodium, potassium and chloride levels were lower than the normal range, preoperatively. The pulse rate, rectal temperature, neutrophil count, monocyte count and alanine transferase, aspartate transferase levels were within the normal range, preoperatively. In lower alimentary tract obstruction (Group II), constipation was the prominent symptom observed. The faeces was either tarry or blood tinged. The frequency of vomiting was three times or less a day and vomitus was either frothy or yellowish in colour with presence of partially digested food materials. Pain on abdominal palpation was noticed in five animals. The systolic and diastolic blood pressure, neutrophil count and blood urea nitrogen, creatinine, serum albumin, aspartate transferase, alanine transferase levels were higher than the normal range, preoperatively. The packed cell volume, total erythrocyte count, monocyte count and serum sodium, potassium and chloride levels were lower than the normal range preoperatively. The respiration rate, pulse rate, rectal temperature, total leukocyte count, haemoglobin concentration, lymphocyte count and total serum protein level were within the normal range, preoperatively. Plain radiography was found useful for identifying the obstruction in the alimentary tract caused by radio opaque materials. Contrast radiography using barium meal revealed seats of obstructions due to radiolucent foreign bodies and anatomical alterations.ThesisItem Open Access Clinical evaluation of xylazine-propofol anaesthesia in dogs(Department of Surgery, College of Veterinary and Animal Sciences, Mannuthy, 2001) Sooryadas, S; KAU; Sarada Amma, TThe study was undertaken to evaluate the anaesthetic effect of propofol in xylazine premedicated canine surgical patients. Fifteen dogs of different breeds of either sex were divided into two groups. Group I consisted of eight apparently healthy dogs presented for elective surgery, and group 11 consisted of seven dogs presented for emergency surgery. All the animals were premedicated with atropine sulphate @ 0.04 mg/kg body weight IM and xylazine @ 1 mg/kg IM. Ten minutes later, general anaesthesia was effected with intravenous injection of 1 % w/v propofol and was maintained with incremental dose(s) ofpropofol as intermittent boli as and when required. Palpebral reflex was sluggish ill both groups during induction and throughout the period of maintenance. Eyeball rolled down during induction and remained in that position throughout the period of maintenance. The duration of anaesthesia after initial bolus was 14.03 ± 2.04 min. in group I and 18.54 ± 1.64 min. in group 11. The average incremental dose of propofol needed was 2.78 ± 0.45 mg/kg in group I and 2.98 ± 0.50 mg/kg in group H. The average duration of effect of incremental dose obtained was 10.04 ± 0.75 min. in group I and 16.85 ± 2.71 min. in group H. Animals of group I were able to stand by 14.72 ± 1.63 min. after recovery while it was 20.9 ± 1.25 min. in group Il. The gait of the animals of group I became apparently normal by 19.69 ± 1.55 minutes, while it was 27.2 ± 3.06 minutes in group II animals. Respiration rate showed significant decrease in both the groups after premedication and at 15 minutes after induction with propofol. Pulse rate and heart rate decreased after premedication and increased on induction with propofol. Electrocardiographic changes were transient. There was decrease in haemoglobin concentration after premedication, which increased on induction in both groups. Total erythrocyte count decreased on premedication and increased on induction. Total leukocyte count decreased after premedication followed by an increase after induction. Neutrophilia was observed both after premedication and on induction with propofol in group I, where as in group II neutrophil count showed a decrease on premedication which increased after induction. Lymphocyte count decreased after premedication and increased after induction in group 1. But in .group II lymphocyte count showed an increase after premedication, which decreased on induction of anaesthesia. Serum sodium and potassium concentrations, total serum protein content and albumin/globulin ratio did not show any significant change during the study .. Propofol under atropine-xylazine premedication was found to be an effective and safe anaesthetic for. induction and maintenance of anaesthesia for surgery in both healthy and compromised dogs with less side effects.ThesisItem Open Access Management of tibial fractures in dogs using plaster of paris cast and modified thomas splint(Department of Surgery, College of Veterinary and Animal Sciences, Mannuthy, 2001) Anoop, S; KAU; Balagopalan, T PThe study was undertaken with the objectives of 1. Assessing the healing process based on clinical symptoms, biochemical parameters and radiography of the affected part after immobilization of tibial fractures with plaster of Paris cast and modified Thomas splint. 2. Assessing the effect of electrodiagnostic procedures on healing of fracture of tibia in dogs. The study was conducted in twelve selected clinical cases of fracture of tibia in dogs of either sex presented to the Department of Surgery. These animals were randomly divided into two groups (group 1 and group 11) consisting of six animals each. All the animals were examined clinically and radiographically and observations were recorded. They were premedicated with Atropine sulphate (0.04 mg/kg body weight) intramuscular followed by xylazine hydrochloride (1 mg/kg body weight) intramuscular. The fracture was reduced by closed method in all the animals. The limb was immobilized by application of modified Thomas Splint in Group 1 and by application of plaster of Paris cast in group 11. History and observations on clinical and physiological parameters, haemogram, serum constituents, radiography of the limb and electrodiagnostic procedures were recorded in all the animals on the day of presentation and at the end of first week, second week, third week and sixth week after immobilization. All the animals were kept under observation for a period of six weeks. Though 30 per cent of the animals in each group started bearing weight on the affected limb by the end of first week, fracture instability and other associated symptoms persisted relatively more in animals of group 1. At the end of second week, the symptoms of fractures except oedema were found to be persisting in more number of animals belonging to group 1 due to mutilation of the Thomas splint. By third week all the animals in group 11 could bear weight on the affected limb but limb dysfunction still persisted in fifty per cent of the animals in group 1. By the end of sixth week all the animals in both the groups showed apparently normal use of the limb. Temperature, pulse rate and respiration rate showed variation within normal range during the period of observation in all the animals. Haemoglobin concentration, packed cell volume, total erythrocyte count and lymphocyte count showed marginal increase on first week post fracture followed by a decrease thereafter in all the animals of both the groups. But neutrophil count showed a fall on the first week post fracture followed by a gradual increase in group 1, but in group 11 it revealed a decrease in values throughout the period of observation. Eosinophil and monocyte count showed only marginal variations during the period of observation in both the groups. Serum total protein showed a decrease till second week followed by an increase in group 1 but the variation was marginal in group 11. Serum alkaline phosphatase showed an increase till second week followed by a decrease thereafter in both the groups. Serum aspartate amino transaminase values remained at a higher level in the post fracture period in group 1 but in group 11 it was relatively at a lower level. Periosteal callus started developing near the fracture site along with reduction in soft tissue swelling and opacity of fragment ends in four animals in group 1 and two animals in group 11 by the end of first week. Five animals in group 1 and four animals in group 11 showed presence of massive periosteal callus by the end of third week and three animals in group 11 and two animals in group 1 showed presence of smooth and opaque periosteal callus with complete disappearance of fracture line by the end of sixth week. Eventhough there was marginal increase in the strength required to produce minimal contractile response in the initial period after fracture reduction, by sixth week, the values were near normal at all the duration in both the groups.