Clinical evaluation of xylazine-propofol anaesthesia in dogs
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Date
2001
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Department of Surgery, College of Veterinary and Animal Sciences, Mannuthy
Abstract
The study was undertaken to evaluate the anaesthetic effect of propofol in xylazine premedicated canine surgical patients.
Fifteen dogs of different breeds of either sex were divided into two groups. Group I consisted of eight apparently healthy dogs presented for elective surgery, and group 11 consisted of seven dogs presented for emergency surgery. All the animals were premedicated with atropine sulphate @ 0.04 mg/kg body weight IM and xylazine @ 1 mg/kg IM. Ten minutes later, general anaesthesia was effected with intravenous injection of 1 % w/v propofol and was maintained with incremental dose(s) ofpropofol as intermittent boli as and when required. Palpebral reflex was sluggish ill both groups during induction and throughout the period of maintenance. Eyeball rolled down during induction and remained in that position throughout the period of maintenance. The duration of anaesthesia after initial bolus was 14.03 ± 2.04 min. in group I and 18.54 ± 1.64 min. in group 11. The average incremental dose of propofol needed was 2.78 ± 0.45 mg/kg in group I and 2.98 ± 0.50 mg/kg in
group H. The average duration of effect of incremental dose obtained was 10.04 ± 0.75 min. in group I and 16.85 ± 2.71 min. in group H. Animals of group I were able to stand by 14.72 ± 1.63 min. after recovery while it was 20.9 ± 1.25 min. in group Il. The gait of the animals of group I became apparently normal by 19.69 ± 1.55 minutes, while it was 27.2 ± 3.06 minutes in group II animals. Respiration rate showed significant decrease in both the groups after premedication and at 15 minutes after induction with propofol. Pulse rate and heart rate decreased after premedication and increased on induction with propofol. Electrocardiographic changes were transient. There was decrease in
haemoglobin concentration after premedication, which increased on induction in both groups. Total erythrocyte count decreased on premedication and increased on induction. Total leukocyte count decreased after premedication followed by an increase after induction. Neutrophilia was observed both after premedication and on induction with propofol in group I, where as in group II neutrophil count showed a decrease on premedication which increased after induction. Lymphocyte count decreased after premedication and increased after induction in group 1. But in .group II lymphocyte count showed an increase after premedication, which decreased on induction of anaesthesia. Serum sodium and potassium concentrations, total serum protein content and albumin/globulin ratio did not show any significant change during the study .. Propofol under atropine-xylazine premedication was found to be an effective and safe anaesthetic for. induction and maintenance of anaesthesia for surgery in both healthy and compromised dogs with less side effects.
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