Loading...
Thesis
Browse
29 results
Search Results
ThesisItem Open Access PHARMACOKINETICS OF MEBENDAZOLE IN BUFFALO CALVES, GOATS AND POULTRY(Birsa Agricultural University, 1988) PANDEY, SACHIDA NAND; Banarjee, N.C.A simple spectrophotometric method for mebendazole estimation in the biologicals has been developed after modification of the analytical procedure described by frey and keller. kinetic parameters of mebendazole in buffalo calves, goats and poultry have been determined. The kinetic basis for optimal utilization of plasma drug level dats has been discussed.ThesisItem Open Access PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING OF KARANJ(Birsa Agricultural University, 1988) Sinha, Kameshwar Prasad; Banarjee, N.C.1. Phytochemical tests conducted evidenced presence of alkaloid in both aqueous and ether extracts of the seeds of P. glabra whereas glycoside was found only in ether extract. 2. The presence of identifiable I.R. bands at 3060, 2960, 1460-70, 870 and 740 cm-1 has evidenced presence of -0-and OCH groups in the ether extract: A band at 1360 cm1 evidenced the presence of a secondary alcoholic/phenolic group also. 3. The humps observed in the U.V. spectra at 218, 250 and 285 no evidenced presence of phenoxymethyl group in the extracts. 4. It has been evidenced that in both the extracts methoxyfurano-flavone structure was present, which showed structural similarity with serotonin. 5. It has been analytically evidenced for the first time that a fair concentration of the active principle was present in the blood of mice after oral administration of the test extracts. 6. It has been evidenced by Infrared spectroscopy that the OCH group of the active principle was biotransformed in the mice apparently by demethylation processThesisItem Open Access EFFECT OF PYROGEN INDUCED FEVER ON BIOKINETICS OF DULFADIMIDINE AND ITS INTERACTION WITH SALICYLATE IN GOATS(Birsa Agricultural University, 1988) DUTTA, RANJIT KUMAR; YADAVA, K.P.1.'Goat fever model was constructed with two successive LPS endotoxin injections given at zero and 5 hr which maintained fever above 0.83°c upto 12 hr. 2. It was observed that the mean CPmax and CPmin of free SDD following i.v. administration were higher and the duration of CP ther was longer in febrile (SDD-F) than the corresponding values observed for normal (SDD-N) group as reflected in 30.14% increase in the plasma half life which suggested increased ionization of the drug at lowered plasma pH and consequent 'ion trapping' in febrile goats. 3. An overall higher mean plasma concentration of SDD in (SDD+SSA-N) group with 20.66% increase in plasma half life as compared to that in (SDD-N) group correlated well with the slower rate and extent of SDD biotransformation due to its interaction with SSA. 4. Evidence was adduced that the overall sojourn and the CP ther of SDD were longer with 29.41% increase in the plasma half life in febrile (SDD-F) as compared to that in (SDD+SSA-F) group following i.v. dose which indicated plasma protein binding competition with SDD and subsequent elimination of SDD in the febrile interaction group. 5. It was observed that mean CPmax and Cpuin were found to be higher in (SDD+SSA-F) as compared to that in (SDD+SSA-N) group following concomitant i.v. SDD+SSA administration;ThesisItem Open Access PHARMACOKINETICS OF BETAMETHASONE AND ITS EFFECT ON THE BIOCHEMICAL AND HAEMATOLOGICAL PARAMETERS IN GOATS(Birsa Agricultural University, 1985) Ahmad, ABUL HASAN; Banarjee, N.C.From the studies made in this project on soils, developed from the game parent material – Granite gneiss, under similar climate conditions but differing in land situations and management practices, the following conclusions can be drawn in respect of the variations in their properties. A. Land situations (upland v/s medium land) 1. Uplands have sandy loam texture under farmers practice while medium land have sandy loan to loam texture. 2. Bulk density and moisture retention at 15 bar and 1/3 bar at 15- 30 cm depth are more on uplands. 3. Porosity and aggregation are less on uplands. 4. Ph, w/s AL& CEC are low on uplands.ThesisItem Open Access Pharmacokinetics of metronidazole in ruminants and its effect on the Haematological and biochemical parameters with special reference to Goats(Birsa Agricultural University, 1984) Mandal, Tapan Kumar; Yadava, K.P.1.Thesemilogarithmic plot of blood level-time profile obtained in buffalo calves after I/V administration of MNZ 20 mg/kg b.w. showed biphasic decay which indicated" two compartment open model " disposition kinetics of MNZ in consonance with first order kinetics. 2. It has been observed that MNZ given I/V as a single dose 20 mg/g b.w. in buffalo calves produced CB ther above 0.7 ug/ml upto 6 hr post-administration. 3. It has been evidenced that tk (3) of MNZ in buffalo calves was 155.00+10.58 min while the Cl, value was 4.38+0.23 ml//min suggesting rapid elimination of the compound. The V'd value determined was 0.98+0.09 L/ which indicated its penetration into total body water spaces. 4. Evidence has been adduced that the buffalo plasma protein binding of MNZ ranged between 21.54 to 65.35% at plasma drug concentration ranging from 200 to 25 ug/ml. 5.It has been observed that MNZ concentration in buffalo erythrocytes (6.8 x 109/ml) ranged from 10.30 to 22.74ug/ml at a total blood drug concentration ranging between 400 to 50 ug/ml which suggested significant erythrocyte uptake of the compoundThesisItem Open Access Pharmacokinetics of some chemotherapeutic agents in poultry(Birsa Agricultural University, 1981) Yadava, Kameshwar Prasad; Banarjee, N.C.SUMMARY AND CONCLUSION 1. It has been observed that sulfonamides were absorbed from the G. I. tract of birds as per pH-pka relationship. 2. Evidence has been adduced that following single dose oral administration, sulfadimethoxine, sulfamethazine, spanbolets and sulfaquinoxaline showed max) at different time intervals indicating variation in their absorption rate from the G.1. tract of birds. 3. It has been observed that sulfadimethoxine showed the highest (max) followed by sulfamethasine, spanbolets and sulfequinoxaline post-single dose oral administration. 4. Evidence has been presented that sulfadimethoxine and sulfamethasine produced effective ther) for a longer duration of time indicating their therapeutic usefulness in the systemic infections in the chickens. 5. It was observed that sulfadimethoxine gave the longest by value followed by sulfamethazine, spanbolets and sulfaquinoxeling. 6. Evidence has been adduced that the total area under the blood level-time profile (AUC) obtained after multiple oral dose administration was largest for sulfadimethoxine followed by sulfamethazine, spanbolets and sulfaquinoxaline indicating their relative bioavailability. 7. It has been observed that acetylation was one of the major pathway of aulfonamide metabolism in the chicken and the rate and extent of this biotransformation varied with different sulfonamide compounds.ThesisItem Open Access Pharmacokinetics sulfadimethoxine in Buff - Calves(Birsa Agricultural University, Ranchi, 1983) Sharma, Madhududan; Banerjee, N.C.1.The results obtained indicated that after single dose 1/V administration of sulfadimethoxine the plasma level of the free therapeutically active drug concentration wan 2.02 mg% till 6 hr. 2. It has been evidenced that in buffalo calves, sulfadine thoxine was deactivated to form its acetylated and glucuronide derivatives. 3. It was recorded that the highest mean percent acetylation in the plasma was 31.11 and highest glucuronide conjugation was 29.03 percent. 4. It was evidenced that the extent of acetylation and glucuro nide conjugation of sulfadimethoxine in the plasma of buffalo, calves after I/V administration were very similar. 5. It was observed that efter single dose I/V administration 50 mg/q b.., the free drug was excreted rapidly and in higher concentration through the urine. 6. It was determined that the free therapeutic active drug concentration ranged from 4.50-0.22 to 48.15-2.39 mg til1 24 hrs. This indicated that the drug could be fruitfully used clinically in urinary tract infections for a longer duration. 7. It was observed that the percent acetylated derivative of the compound excreted through the yine (38.18) was higher than has been reported in cattle (32%).ThesisItem Open Access EVALUATION OF WOUND HEALING POTENTIAL OF POLY HERBAL FORMULATION (Clerodendron infortunatum + Curcuma longa+ Aloe vera ) IN DIABETIC RATS(Birsa Agricultural University, Ranchi, Jharkhand-6, 2018) ., Dipshikha; Prasad, RajuIt can be concluded from above results that the polyherbal ointment application showed faster and organised wound healing in diabetic rats which is evidenced by higher % wound contraction, increased anti oxidative enzymes, reduced LPO and more hydroxy proline content in treated group. It is also supported by histopathological studies of granulation tissues. The Aloe vera • The findings suggested that the polyherbal treatment (CI:AV:CL = 4:7:1) have great potential to hasten cutaneous wound healing in diabetic rats on topical application.ThesisItem Open Access PHARMACOKINETIC STUDIES OF LEVOFLOXACIN IN HEALTHY AND FEBRILE CALVES(Birsa Agricultural University, Kanke, Ranchi, Jharkhand, 2007) kumar, Santosh; Roy, B. K.The pharmacokinetic studies of LVX after oral (20 mg/kg) and i.v. (5 mg/kg) administration were conducted in six healthy and febrile calves. The mean value of Cpmax of LVX (4.50 ± 0.22 μg/ml) after single dose oral administration in healthy calves was significantly lower as compared to that in febrile calves (5.28 ± 0.32 μg/ml). The Cpther of LVX was maintained for longer period in febrile calves (till 10 h) as compared to healthy calves (till 8 h). The mean value of Cumax in febrile (40.86 ± 2.19 μg/ml) was similar to that in healthy calves (39.38 ± 2.43 μg/ml). The non-significant difference in various pharmacokinetic parameters of plasma viz. , t½, and MRT was observed after oral administration of LVX in healthy and febrile calves. The non-significant difference in various pharmacokinetic parameters of urine viz. Cumax, , t½ observed after oral administration of LVX in healthy and febrile calves. The mean value of Cpmax of LVX after single dose i.v. (5 mg/kg) in febrile calves (6.16 ± 0.15μg/ml) was significantly higher as compared to that in healthy calves (5.13 ± 0.13 μg/ml). The Cpther of LVX was prolonged in febrile calves (till 8 h) in febrile calves as compared to healthy (till 6h) after i.v. administration. The value of Cumax of LVX in healthy calves (53.70 ± 2.37μg/ml) was significantly lower than as compared to 63.15 ± 3.44μg/ml in febrile calves. The mean values of t½ , MRT, ClB, Vdarea and T/P differed significantly between healthy and febrile calves after i.v. administration. The results indicated that levofloxacin was readily absorbed after oral administration and diffused thoroughly in body fluids, after both oral and i.v. administration. LVX may be clinically used to combat sensitive microbial infections of urinary tract after oral as well as i.v. administration. LVX may be given orally @ 1.49 – 2.23 mg/kg (1.5 – 2 mg/kg) b.w. in febrile calves every 8 hourly. The i.v. dose of LVX in febrile calves may be 0.58 – 0.87 mg/kg (0.5 – 1 mg/kg) b.w. 6 hr interval
